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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2782074/
While these cationic lipidic systems can facilitate siRNA delivery due to their efficient interaction with cell membranes and nucleic acids, concerns regarding their safety use in vivo have been raised by a recent study performed by Wu and colleagues .Author: Sherry Y. Wu, Nigel A. J. McMillan
https://www.ncbi.nlm.nih.gov/pubmed/19757082
Lipidic systems for in vivo siRNA delivery. Wu SY(1), McMillan NA. Author information: (1)Diamantina Institute for Cancer, Immunology and Metabolic Medicine, University of Queensland, Level 4, R-Wing, Princess Alexandra Hospital, Ipswich Rd, Buranda, QLD, 4102, Australia.Author: Sherry Y. Wu, Nigel A. J. McMillan
https://link.springer.com/10.1208/s12248-009-9140-1
Sep 09, 2009 · Various delivery vectors including liposomes, polymers, and nanoparticles have thus been developed in order to circumvent these problems. This review presents a comprehensive overview of the barriers and recent progress for both local and systemic delivery of therapeutic siRNA using lipidic …Author: Sherry Y. Wu, Nigel A. J. McMillan
https://europepmc.org/articles/PMC2782074
LOCAL DELIVERY OF siRNA USING LIPIDIC SYSTEMS Local delivery of siRNA is ideal for diseases where the target sites are easily accessible, such as skin or mucosal surfaces.
https://mdanderson.elsevierpure.com/en/publications/lipidic-systems-for-in-vivo-sirna-delivery
title = "Lipidic systems for in vivo siRNA delivery", abstract = "The ability of small-interfering RNA (siRNA) to silence specific target genes not only offers a tool to study gene function but also represents a novel approach for the treatment of various human diseases.Author: Sherry Y. Wu, Nigel A. J. McMillan
https://core.ac.uk/display/15081546
Various delivery vectors including liposomes, polymers, and nanoparticles have thus been developed in order to circumvent these problems. This review presents a comprehensive overview of the barriers and recent progress for both local and systemic delivery of therapeutic siRNA using lipidic vectors.Author: Sherry Y. Wu, Nigel A. J. McMillan
https://www.nature.com/articles/gt2010113
Aug 12, 2010 · Although the successful use of polyethylene glycol (PEG)ylated lipidic delivery systems have already been reported, most of the formulation procedures used are labour intensive …Author: Sherry Wu, A. Singhania, M. Burgess, L. N. Putral, C. Kirkpatrick, N. M. Davies, N. A.J. McMillan
https://pubs.acs.org/doi/abs/10.1021/bi048950a
Efficient In Vivo Delivery of siRNA to the Liver by Conjugation of α-Tocopherol. Molecular Therapy 2008, 16 (4) , 734-740. DOI: 10.1038/mt.2008.14. Andrew David Miller. Synthetic Nucleic Acid Delivery Systems in Gene Therapy.Author: Sebastien Spagnou, Andrew D. Miller, Michael Keller
https://www.sciencedirect.com/science/article/pii/S0169409X19300547
One example of a polymeric siRNA delivery system in clinical trials is the Dynamic PolyConjugates system, which enabled >60% silencing of apoB in hepatocytes in vivo at a dose of about 2.5 mg/kg (50 μg siRNA and 800 μg polymer per mouse) .Author: Yizhou Dong, Daniel J. Siegwart, Daniel G. Anderson
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