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https://www.chegg.com/homework-help/questions-and-answers/researchers-always-looking-new-ways-deliver-therapeutic-drugs-bloodstream-distribution-thr-q15313303
Today, however, researchers are looking for wider and more varied uses of epithelial absorption as a drug delivery method. 1. a) Based on what you know of the different epithelial tissue types, which are the best candidates for this type of therapy? Explain your choices. b) How could a clinician actually apply epithelial absorption techniques?
https://pharm.ucsf.edu/desai/research/corneal-tissue-engineering
Epithelial Tissue Engineering & Drug Delivery. Microstructure and nanostructure-mediated transport of biologics across epithelial tissue. Corneal blindness affects more than 10 million people worldwide, with corneal transplants being the only currently available treatment. Issues such as donor shortages and immune rejections have motivated ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362257/
Jun 20, 2018 · Oral delivery of liposomes has a long history as well and can be traced to as early as the late 1970s25., 26., 27..It is interesting to see that the initial application of oral liposomes was with the delivery of insulin28, emphasizing the continual challenge in the field of oral drug delivery.Despite the initial ardor, the efficacy of oral liposomes was not reproducible or predictable.Author: Haisheng He, Yi Lu, Jianping Qi, Quangang Zhu, Zhongjian Chen, Wei Wu
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3291189/
Nov 22, 2011 · Absorption enhancers are functional excipients included in formulations to improve the absorption of a pharmacologically active drug. The term absorption enhancer usually refers to an agent whose function is to increase absorption by enhancing membrane permeation, rather than increasing solubility, so such agents are sometimes more specifically termed permeation enhancers.Author: Bruce J. Aungst
https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/oral-drug-delivery
Umesh Gupta, Omathanu Perumal, in Natural and Synthetic Biomedical Polymers, 2014. 15.5.1.2 Oral Drug Delivery. Oral drug delivery is the most preferred drug administration route due to convenience, cost-effectiveness, and high patient compliance. The challenges in oral drug delivery include aqueous solubility, membrane permeability, and chemical and enzymatic stability of drugs.
https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/intestinal-drug-absorption
Intestinal drug absorption can be improved by altering paracellular and transcellular transport pathways using permeation enhancers (Figure 8.1) [16–19].Permeation enhancers have different mechanisms of action, including the induction of a loss of integrity of the cell–cell tight junctions, changes in mucus viscosity, modulation of membrane structure and fluidity – associated with ...
https://www.mattek.com/application/drug-delivery-3/
Drug Delivery (Oral Mucosal) The Model. MatTek’s EpiOral tissues consist of normal, human-derived epithelial cells. The tissues, which are cultured on specially prepared cell culture inserts using serum free medium, attain levels of differentiation on the cutting edge of in vitro cell culture technology.
https://www.pharmacologyeducation.org/pharmacology/drug-absorption
For drug absorption to occur, a drug must cross biologic barriers (e.g. epithelial/endothelial cells, etc.). Only a few drugs move across cellular barriers in an “active” way; that is, a way that requires energy (ATP) and moves the drug from an area of low concentration to an area of higher concentration.
https://www.nature.com/articles/s41598-017-18561-x
Jan 09, 2018 · Further advantages for systemic drug delivery via the nasal route include its large surface area for drug absorption and the associated avoidance of hepatic first-pass metabolism and drug ...Author: Dongjoo Kim, Young Hyo Kim, Soonjo Kwon
https://www.mattek.com/application/epithelial-restitution/
The injured tissues were analyzed daily for epithelial restitution using phase contrast microscopy, confocal imaging of migrating epithelial cells (immuno-stained for cytokeratin 19) and fibroblasts (immuno-stained for vimentin), transepithelial electrical resistance (TEER) measurements to monitor recovery of epithelial barrier integrity, and H ...
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