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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3507026/
Jul 06, 2012 · INTRODUCTION. Basically gene therapy is an intracellular delivery of genomic materials (transgene) into specific cells to generate a therapeutic effect by correcting an existing abnormality or providing the cells with a new function.[] Different types of gene delivery systems may be applied in gene therapy to restore a specific gene function or turning off a special gene(s).
https://en.wikipedia.org/wiki/Gene_delivery
Gene delivery is the process of introducing foreign genetic material, such as DNA or RNA, into host cells. Genetic material must reach the nucleus of the host cell to induce gene expression. Successful gene delivery requires the foreign genetic material to remain stable within the host cell and can either integrate into the genome or replicate independently of it.
https://www.ncbi.nlm.nih.gov/pubmed/12774942
Electro-gene-transfer: a new approach for muscle gene delivery. ... Gene transfer into skeletal muscle cells by direct injection of naked plasmid DNA results in sustained gene expression. Intramuscular injection of plasmid DNA might thus be used to correct myopathies, to secrete locally or systematic therapeutic proteins and to elicit an immune ...Author: Elena Fattori, Nicola La Monica, Gennaro Ciliberto, Carlo Toniatti
https://www.drugs.com/vet/electrosol-injection.html
ElectroSol™ Injection pH 7.4 (Multiple Electrolytes Injection, Type 1, USP) should be used with caution. Excess administration may result in metabolic alkalosis. Caution must be exercised in the administration of ElectroSol™ Injection pH 7.4 (Multiple Electrolytes Injection, Type 1, USP) to patients receiving corticosteroids or corticotropin.
https://www.slideshare.net/Disisnups/gene-delivery-system-39372835
Sep 22, 2014 · GENE DELIVERY SYSTEM-Introduction- Gene delivery is the process of introducing foreign DNA into host cells. Techniques are available for the introduction of DNA or RNA into hundreds of different cell types in culture, and such experiments can be used to study gene function and regulation, to produce recombinant proteins and to manipulate the ...
https://www.thermofisher.com/us/en/home/life-science/cell-culture/transfection/transfection-support/gene-delivery-selection-guide.html
Researchers have a wide variety of gene delivery techniques to introduce plasmid DNA, siRNA or duplex RNAi, oligonucleotides, and RNA into eukaryotic cells for a …
https://www.hindawi.com/journals/bmri/2015/610342/
Gene therapy can be defined as incorporation of genetic material, that is, DNA or RNA, in the cellular gene regulation system, either to correct the expression of a malfunctioning gene or to modulate the cellular functions through expression of the newly incorporated gene.Author: Surendra Nimesh, Sabina Halappanavar, Nagendra K. Kaushik, Pradeep Kumar
https://engineering.jhu.edu/materials/research-projects/polymeric-nanoparticles-for-gene-delivery/
Polymeric Nanoparticles for Gene Delivery. The aim of this study is to investigate the structure-transfection efficiency relationship of PPA gene carriers; and to investigate the effect of PPA structure on DNA compaction ability of PPA, stability of PPA/DNA nanoparticles in physiological medium, cellular uptake efficiency, intracellular ...
https://www.sciencedirect.com/science/article/pii/S0889858805700046
If one is treating a chronic disease and has to repeat gene delivery over a long time, the accrued number of insertional events could increase the chances for developing a malignancy, but such a risk could be small, given the fact that development of cancer is a multistep, multifactorial process.Author: Nelson A. Wivel, James M. Wilson
https://www.intechopen.com/books/application-of-nanotechnology-in-drug-delivery/electroporation-advantages-and-drawbacks-for-delivery-of-drug-gene-and-vaccine
Electroporation was introduced in the 1960s and comprises the application of controlled electric fields to facilitate cell permeabilization. The success of in vitro delivery by electroporation has led to the development of in vivo applications [Takei et al., 2008].The first in vitro and in vivo attempts to use electroporation in gene transfer were demonstrated in 1982 and 1991, respectively ...Author: Azam Bolhassani, Afshin Khavari, Zahra Orafa
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