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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3109217/
Electroporation Enhanced DNA Vaccine Delivery. Electroporation (EP) is a method to introduce macromolecules such as nucleic acids into cells, either in vivo or in vitro, via the application of brief electric pulses to induce transient and reversible permeabilization of the cell membrane (Figure 1).Author: Niranjan Y Sardesai, David B Weiner
https://www.nature.com/articles/s41598-017-04547-2
Jun 23, 2017 · Electroporation as a vaccine delivery system and a natural adjuvant to intradermal administration of plasmid DNA in macaques Skip to main content Thank you for visiting nature.com.Author: Biliana Todorova, Lucille Adam, Slobodan Culina, Raphaël Boisgard, Frédéric Martinon, Antonio Cosma,...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2835112/
Mar 31, 2009 · Electroporation (EP) has been used in basic research for the past 25 years to aid in the transfer of DNA into cells in vitro. EP in vivo enhances transfer of DNA vaccines and therapeutic plasmids to the skin, muscle, tumors, and other tissues resulting in high levels of expression, often with serological and clinical benefits.Author: Angela M Bodles-Brakhop, Richard Heller, Ruxandra Draghia-Akli
https://www.intechopen.com/books/application-of-nanotechnology-in-drug-delivery/electroporation-advantages-and-drawbacks-for-delivery-of-drug-gene-and-vaccine
Electroporation has proven useful both in vitro, in vivo and in patients, where drug delivery to malignant tumors has been performed. In addition, the data show that electroporation of DNA vaccines in vivo is an effective method to increase cellular uptake of DNA and gene expression in tissue leading to marked improvement in immune responses.Author: Azam Bolhassani, Afshin Khavari, Zahra Orafa
https://www.sciencedirect.com/science/article/pii/S0952791511000331
Electroporation enhanced DNA vaccine delivery Electroporation (EP) is a method to introduce macromolecules such as nucleic acids into cells, either in vivo or in vitro, via the application of brief electric pulses to induce transient and reversible permeabilization of the cell membrane (Figure 1).Author: Niranjan Y Sardesai, David B Weiner
https://www.inovio.com/technology/electroporation-delivery/electroporation-devices/
Inovio has developed the CELLECTRA electroporation device to efficiently deliver DNA plasmids into cells where they can be expressed to generate robust antibody and T cell responses. Electroporation has also been shown to recruit and trigger cells involved in antigen presentation and immune response, further augmenting the benefits of superior DNA delivery.
https://www.sciencedirect.com/topics/agricultural-and-biological-sciences/electroporation
Indeed, electroporation has even been used successfully in human trials for gene delivery for the treatment of tumors and for vaccine development. Electroporation can lead to between 100 and 1000-fold increases in gene delivery and expression and can also increase both the distribution of cells taking up and expressing the DNA as well as the absolute amount of gene product per cell (likely due to increased delivery …
https://www.prnewswire.com/news-releases/inovios-cellectra-electroporation-delivery-technology-powers-durable-best-in-class-t-cell-responses-from-hiv-vaccine-in-human-study-214867291.html
Inovio's patented CELLECTRA electroporation delivery technology uses controlled, millisecond electrical pulses to create temporary pores in the cell membrane and allow significant cellular uptake...
https://www.nature.com/articles/nrd.2017.243
Jan 12, 2018 · mRNA vaccines represent a promising alternative to conventional vaccine approaches because of their high potency, capacity for rapid development and potential for low-cost manufacture and safe administration.Author: Norbert Pardi, Michael J. Hogan, Frederick W. Porter, Drew Weissman
https://www.researchgate.net/publication/300064623_Electroporation_-_Advantages_and_Drawbacks_for_Delivery_of_Drug_Gene_and_Vaccine
The electroporation delivery was found to be superior to all other test methods. The maximal enhancement in transfection efficiency by electroporation was …
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