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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3887097/
Apr 01, 2013 · To improve the delivery of pharmaceutical agents through tissue barriers, drug enhancing methods have been developed. The largest body of information on a drug enhancer is available for caprate, as this is the best investigated agent for this purpose and has been used in clinical studies.Author: Christian Tscheik, Ingolf E. Blasig, Lars Winkler
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2895432/
May 01, 2010 · Ocular drug delivery has been a major challenge to pharmacologists and drug delivery scientists due to its unique anatomy and physiology. Static barriers (different layers of cornea, sclera, and retina including blood aqueous and blood–retinal barriers), dynamic barriers (choroidal and conjunctival blood flow, lymphatic clearance, and tear dilution), and efflux pumps in conjunction pose a ...Author: Ripal Gaudana, Hari Krishna Ananthula, Ashwin Parenky, Ashim K. Mitra
https://www.sciencedirect.com/science/article/pii/S0928098713001395
Non-parenteral delivery of drugs using nanotechnology-based delivery systems is a promising non-invasive way to achieve effective local or systemic drug delivery. The efficacy of drugs administered non-parenterally is limited by their ability to cross biological barriers, …Author: Ivan Pepić, Jasmina Lovrić, Jelena Filipović-Grčić
https://www.researchgate.net/publication/236338421_How_do_polymeric_micelles_cross_epithelial_barriers
Polymeric micelles can achieve transepithelial drug delivery because of their ability to be internalized into cells and/or cross epithelial barriers, thereby delivering drugs either locally or ...
https://onlinelibrary.wiley.com/doi/full/10.1111/bcpt.12342
Oct 27, 2014 · Mucus is thus a highly complex gel barrier to drug delivery. Current knowledge of mucus characteristics and barrier properties, as achieved by state‐of‐the‐art methodologies, is the topic of this MiniReview emphasizing the gastrointestinal mucus and an overall focus on oral drug delivery.Author: Marie Boegh, Hanne Mørck Nielsen
https://www.sciencedirect.com/science/article/pii/S0005273608003040
The epithelial and endothelial barriers of the human body are major obstacles for drug delivery to the systemic circulation and to organs with unique environment and …Author: Mária A. Deli
http://fplreflib.findlay.co.uk/images/pdf/Claus-Michael-Lehr.pdf
Drug Delivery = getting molecules to their site of action; Lungs Skin Intestinal mucosa Monolayers of alveolar epithelial cells Barriers and Models for Drug Delivery in Health and Disease Carriers and Technologies for Delivering Antiinfectives and Vaccines Bacterial Barriers Biofilms Bacterial Host cell envelop Vacuole Vacuole Shigella ...
https://pubs.acs.org/doi/abs/10.1021/acsami.7b16524
Nanoparticles (NPs) for oral delivery of peptide/protein drugs are largely limited due to the coexistence of intestinal mucus and epithelial barriers. Sequentially overcoming these two barriers is intractable for a single nanovehicle due to the requirements of different or even contradictory surface properties of NPs. To solve this dilemma, a mucus-penetrating virus-inspired biomimetic NP with ...Author: Jiawei Wu, Yaxian Zheng, Min Liu, Wei Shan, Zhirong Zhang, Yuan Huang
https://inventions.prf.org/innovation/6539
One of the most common practices of drug delivery is by the oral route. However, overcoming the gastrointestinal epithelial barriers is the major challenge for efficient delivery of drugs. Besides the intracellular route or passive diffusion, the paracellular route can be exploited by using a bacterial peptide for enhanced delivery of drugs ...
https://www.researchgate.net/publication/303848268_Introduction_for_the_special_issue_on_recent_advances_in_drug_delivery_across_tissue_barriers
Introduction for the special issue on recent advances in drug delivery across tissue barriers. ... while the second struggled with biological barriers. Controlled drug delivery systems can be made ...
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