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https://www.ncbi.nlm.nih.gov/pubmed/23316711
INTRODUCTION: The epithelial cell adhesion molecule (EpCAM) is abundantly expressed in epithelial tumors, on cancer stem cells and circulating tumor cells. Together with its role in oncogenic signaling, this has sparked interest in its potential for tumor targeting with antibodies and drug conjugates for safe and effective cancer therapy.Author: Manuel Simon, Nikolas Stefan, Andreas Plückthun, Uwe Zangemeister-Wittke
https://www.researchgate.net/publication/234131773_Epithelial_cell_adhesion_molecule-targeted_drug_delivery_for_cancer_therapy
Epithelial cell adhesion molecule-targeted drug delivery for cancer therapy Article · Literature Review (PDF Available) in Expert Opinion on Drug Delivery 10(4) · January 2013 with 400 Reads
https://www.bioc.uzh.ch/plueckthun/pdf/APpub0347.pdf
molecule-targeted drug delivery for cancer therapy Manuel Simon, Nikolas Stefan, Andreas Plu¨ckthun & Uwe Zangemeister-Wittke† †University of Bern, Institute of Pharmacology, Bern, Switzerland and University of Zu¨rich, Department of Biochemistry, Zu¨rich, Switzerland Introduction: The epithelial cell adhesion molecule (EpCAM) is abundantly
https://mct.aacrjournals.org/content/6/11/3019
Nov 01, 2007 · Antitumor activity of an epithelial cell adhesion molecule–targeted nanovesicular drug delivery system. Sajid Hussain, Andreas Plückthun, Theresa M. Allen and Uwe Zangemeister-Wittke ... well-tolerated dose levels and suggests further investigations to assess the clinical potential of this nanovesicular drug delivery system for cancer therapy.Author: Sajid Hussain, Andreas Plückthun, Theresa M. Allen, Uwe Zangemeister-Wittke
https://www.ncbi.nlm.nih.gov/pubmed/20727991
Epithelial cell adhesion molecule targeted nutlin-3a loaded immunonanoparticles for cancer therapy. Das M(1), Sahoo SK. Author information: (1)Institute of Life Sciences, Bhubaneswar, India.Author: Manasi Das, Sanjeeb K. Sahoo
https://www.academia.edu/27886618/Epithelial_cell_adhesion_molecule-targeted_drug_delivery_for_cancer_therapy
Epithelial cell adhesion molecule-targeted drug delivery for cancer therapy
https://www.sciencedirect.com/science/article/pii/S1742706110003806
Targeting anti-cancer drug via Ep- CAM receptors could be an upcoming line of treatment against cancer. In the present study, we have developed a novel EpCAM antibody conjugated immunonanocarrier, capable of both drug delivery and molecular targeting to target cancer cells. 4.1.Author: Manasi Das, Sanjeeb K. Sahoo
https://www.nature.com/articles/7700313
Jul 26, 2001 · Application of recombinant adenoviral vectors for cancer gene therapy is currently limited due to lack of specificity for tumor cells. ... Epithelial cell adhesion molecule-targeted drug delivery ...Author: Daniëlle A M Heideman, Peter J F Snijders, Mikael E Craanen, Elisabeth Bloemena, Chris J L M Meijer,...
https://mct.aacrjournals.org/content/5/12/3170
Dec 01, 2006 · Nanoscale drug delivery systems, such as sterically stabilized immunoliposomes binding to internalizing tumor-associated antigens, can increase therapeutic efficacy and reduce toxicity to normal tissues compared with nontargeted liposomes. The epithelial cell adhesion molecule (EpCAM) is of interest as a ligand for targeted drug delivery because it is abundantly expressed in solid tumors but ...Author: Sajid Hussain, Andreas Plückthun, Theresa M. Allen, Uwe Zangemeister-Wittke
https://www.researchgate.net/publication/5822509_Antitumor_activity_of_an_epithelial_cell_adhesion_molecule-targeted_nanovesicular_drug_delivery_system
Antitumor activity of an epithelial cell adhesion molecule-targeted nanovesicular drug delivery system Article (PDF Available) in Molecular Cancer Therapeutics 6(11):3019-27 · December 2007 with ...
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