We have collected information about Endosomal Escape Pathways For Non-Viral Nucleic Acid Delivery Systems for you. Follow the links to find out details on Endosomal Escape Pathways For Non-Viral Nucleic Acid Delivery Systems.
https://www.intechopen.com/books/molecular-regulation-of-endocytosis/endosomal-escape-pathways-for-non-viral-nucleic-acid-delivery-systems
Poor endosomal escape of non-viral systems pose a major challenge for the intracellular delivery of nucleic acids. An ideal nucleic acid delivery system should fulfill several criteria: negligible toxicity, biocompatible and biodegradable, offer protection to nucleic acids from enzymatic degradation, facilitate cellular uptake, promote endosomal escape and release the nucleic acids at site of action.Author: Wanling Liang, Jenny K. W. Lam
https://pdfs.semanticscholar.org/ca49/29cbd8113478dd113fb2590be4b8e338a6c4.pdf
Endosomal Escape Pathways for Non-Viral Nucleic Acid Delivery Systems 431 However, the delivery efficiency of non-viral vectors is generally poor (Pérez-Martínez, Guerra et al. 2011). To enhance transfection efficiency, substantial efforts have been made to elicit effective endosomal escape.
https://www.researchgate.net/publication/284650948_Endosomal_Escape_Pathways_for_Non-Viral_Nucleic_Acid_Delivery_Systems
Non-viral gene delivery systems have attracted growing attention due to their low toxicity, low immunogenicity and ease of production compared to viral vectors. Most non-viral gene delivery systems enter cells via endocytic pathways, and their escape from endosomes is therefore a crucial for successful transfection.
https://www.sciencedirect.com/science/article/pii/S0168365910009053
These include the use of viral proteins, bacterial proteins and especially synthetic biomimetics as endosomal-releasing agents in nucleic acid and protein delivery systems. New synthetic biomimetic peptides are used as endosomal escape reagents; however, their usage is limited because of several potential problems and disadvantages such as immunogenicity and low stability.Author: Amir K. Varkouhi, Marije Scholte, Gert Storm, Hidde J. Haisma
https://www.ncbi.nlm.nih.gov/pubmed/21078351
May 10, 2011 · Thus, a limiting step in achieving an effective biological based therapy is to facilitate the endosomal escape and ensure cytosolic delivery of the therapeutics. Bacteria and viruses are pathogens which use different mechanisms to penetrate the membranes of their target cells and escape the endosomal pathway.Author: Amir K. Varkouhi, Marije Scholte, Gert Storm, Hidde J. Haisma
http://hub.hku.hk/handle/10722/161001
Endosomal escape pathways for non-viral nucleic acid delivery systems. In Ceresa, B (Ed.), Molecular regulation of endocytosis, p. 421-467. Rijeka, Croatia: InTech, 2012
https://pubs.acs.org/doi/10.1021/acs.bioconjchem.8b00732
Many emerging therapies rely on the delivery of biological cargo into the cytosol. Nanoparticle delivery systems hold great potential to deliver these therapeutics but are hindered by entrapment and subsequent degradation in acidic compartments of the endo/lysosomal pathway. Engineering polymeric delivery systems that are able to escape the endosome has significant potential to address this ...Author: Samuel A. Smith, Laura I. Selby, Angus P. R. Johnston, Georgina K. Such
http://onlinelibrary.wiley.com/doi/10.1211/002235703765951311/abstract
Feb 18, 2010 · Many polycation gene delivery systems have tried to mimic the mechanisms that viruses use for the endosomal escape. Polycation gene delivery systems are usually coupled with synthetic amphipathic peptides mimicking viral fusogenic peptides, histidine‐based gene delivery systems for pH‐responsive endosomal escape,...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3507026/
Jul 06, 2012 · INTRODUCTION. Basically gene therapy is an intracellular delivery of genomic materials (transgene) into specific cells to generate a therapeutic effect by correcting an existing abnormality or providing the cells with a new function.[] Different types of gene delivery systems may be applied in gene therapy to restore a specific gene function or turning off a special gene(s).
https://www.ijpsnonline.com/Issues/4681.pdf
In the past few years gene delivery system has gained a huge attention owing to its proved efficacy in several diseases especially in those caused by genetic and/or oncological malfunctioning. The effective gene delivery mainly depends on the carrier molecules that can ensure the safe and specific delivery of the nucleic acid molecules.
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