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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4199305/
Studies in cell culture and animal models revealed that targeted delivery of therapeutics to, into and across endothelium can be achieved using carriers targeted to specific molecules expressed on the surface of the endothelial cells. For example, cell adhesion molecules represent attractive targets …Author: Muzykantov, Muro S
https://www.hindawi.com/journals/isrn/2013/916254/
Endothelial cells represent important targets for therapeutic and diagnostic interventions in many cardiovascular, pulmonary, neurological, inflammatory, and metabolic diseases. Targeted delivery of drugs (especially potent and labile biotherapeutics that require specific subcellular addressing) and imaging probes to endothelium holds promise to improve management of these maladies. In order ...Author: Vladimir R. Muzykantov
https://en.wikipedia.org/wiki/Targeted_drug_delivery
Targeted drug delivery, sometimes called smart drug delivery, is a method of delivering medication to a patient in a manner that increases the concentration of the medication in some parts of the body relative to others. This means of delivery is largely founded on nanomedicine, which plans to employ nanoparticle-mediated drug delivery in order to combat the downfalls of conventional drug ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC538251/
Nov 16, 2004 · Mechanisms for Target Drug Delivery Using Microbubbles. Two possible strategies for delivering drugs and genes with microbubbles are emerging. The first consists on the ultrasound-mediated microbubble destruction, which is based on the cavitation of microbubbles induced by ultrasound application, and the second is the direct delivery of substances bound to microbubbles in …Author: Jeane M Tsutsui, Feng Xie, Richard Thomas Porter
https://www.researchgate.net/publication/258400420_Targeted_Drug_Delivery_to_Endothelial_Adhesion_Molecules
Targeted Drug Delivery to Endothelial Adhesion Molecules Vladimir R. Muzykantov 1,2 1 Center for T arget ed erapeutics and T ra nslational N anomedici ne, I nstitute for Transla tional Medicine ...Author: Vladimir Muzykantov
http://downloads.hindawi.com/archive/2013/916254.pdf
Review Article Targeted Drug Delivery to Endothelial Adhesion Molecules VladimirR.Muzykantov 1,2 Center for Targeteder apeutics and Translational Nanomedici ne, Institute for Translational Medicine & e rapeutics and Department of Pharmacology, University of …Author: Vladimir R. Muzykantov
https://www.nature.com/articles/ncomms15594
Jun 08, 2017 · This approach provides a physically controlled drug delivery method harnessing the biology of endothelial adherens junction and opens a new avenue for drug delivery in a …Author: Yongzhi Qiu, Sheng Tong, Linlin Zhang, Yumiko Sakurai, David R. Myers, Lin Hong, Wilbur A. Lam, Gang...
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0196976
This study reveals that, although local accumulation of the targeted drug was achieved, endothelial targeted dexamethasone containing anti-VCAM-1 SAINT-O-Somes exhibited marginal effects on inflammatory endothelial cell activation in a model of endotoxemia.Author: Ranran Li, Piotr S. Kowalski, Henriëtte W. M. Morselt, Ilona Schepel, Rianne M. Jongman, Adnan Aslan...
https://pubs.acs.org/doi/abs/10.1021/nl3014154
Cationic Thermosensitive Liposomes: A Novel Dual Targeted Heat-Triggered Drug Delivery Approach for Endothelial and Tumor Cells. ... Thermosensitive liposomes with higher phase transition temperature for targeted drug delivery to tumor. International Journal of Pharmaceutics 2014, 475 ...Author: Bilyana M. Dicheva, Timo L. M. ten Hagen, Li Li, Debby Schipper, Ann L. B. Seynhaeve, Gerard C. van ...
https://www.azonano.com/article.aspx?ArticleID=4668
Nov 01, 2017 · The application of nanotechnology for drug delivery provides the potential for enhanced treatments with targeted delivery and fewer side effects. Nanotechnology drug delivery applications occur through the use of designed nanomaterials as well as forming delivery systems from nanoscale molecules such as liposomes.Author: Azonano
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