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https://www.ncbi.nlm.nih.gov/pubmed/21078351
May 10, 2011 · Endosomal escape pathways for delivery of biologicals. Varkouhi AK(1), Scholte M, Storm G, Haisma HJ. Author information: (1)Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Faculty of science, University of Utrecht, Sorbonnelaan 16, 3584 CA Utrecht, The Netherlands.Author: Amir K. Varkouhi, Marije Scholte, Gert Storm, Hidde J. Haisma
https://www.researchgate.net/publication/278214570_Endosomal_escape_pathways_for_delivery_of_biologicals
Endosomal escape pathways for delivery of biologicals Article (PDF Available) in Human Gene Therapy 22(10):A14-A14 · October 2011 with 3,910 Reads How we measure 'reads'
https://www.sciencedirect.com/science/article/pii/S0168365910009053
Facilitating the endosomal escape is an important strategy in therapeutic delivery of biologicals. Different strategies for endosomal escape have different characteristics; A safe endosomal escape agent, should have low immunogenicity and toxicity, high efficiency, ease of use and production, modular attachment of targeting ligands and the ...Author: Amir K. Varkouhi, Marije Scholte, Gert Storm, Hidde J. Haisma
https://www.researchgate.net/publication/47793705_Endosomal_escape_pathways_for_delivery_of_biological
Endosomal escape pathways for delivery of biological Article · Literature Review in Journal of Controlled Release 151(3):220-8 · November 2010 with 6,074 Reads How we measure 'reads'
https://www.sciencedirect.com/science/article/abs/pii/S0168365910009053
Thus, a limiting step in achieving an effective biological based therapy is to facilitate the endosomal escape and ensure cytosolic delivery of the therapeutics. Bacteria and viruses are pathogens which use different mechanisms to penetrate the membranes of their target cells and escape the …Author: Amir K. Varkouhi, Marije Scholte, Gert Storm, Hidde J. Haisma
https://www.rug.nl/research/portal/publications/endosomal-escape-pathways-for-delivery-of-biologicals(eab182c8-8261-45bd-97a9-52eca0ff71df)/export.html
May 10, 2011 · title = "Endosomal escape pathways for delivery of biologicals", abstract = "Despite continuous improvements in delivery systems, the development of methods for efficient and specific delivery of targeted therapeutic agents still remains an issue …Author: Amir K. Varkouhi, Marije Scholte, Gert Storm, Hidde J. Haisma
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0171699
Endosomal escape of macromolecules can happen within a few seconds after PCI when endosome membranes are ruptured photochemically [34,35]. Although endosomal escape is considered to be crucial for gene delivery, an important question is, when is the optimal time for the escape to occur?Author: Lisa D. Cervia, Chun-Chi Chang, Liangli Wang, Fan Yuan
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4091764/
May 21, 2014 · A DNA-Device that Mediates Selective Endosomal Escape and Intracellular Delivery of Drugs and Biologicals Silvia Muro , Associate Professor * S. M. Institute for Bioscience and Biotechnology Resarch & Fischell Department of Bioengineering, University of Maryland College Park, 5115 Plant Sciences Building, College Park, MD 20742, USA.Author: Silvia Muro
https://www.intechopen.com/books/molecular-regulation-of-endocytosis/endosomal-escape-pathways-for-non-viral-nucleic-acid-delivery-systems
Chloroquine promotes escape of polyplexes or lipoplexes from endosome via increasing endosomal pH and hindering endosome fusion with lysosome. To date, chloroquine has been widely used to elucidate the uptake mechanism of non-viral nucleic acid delivery systems (Legendre and Szoka Jr 1992; Simeoni, Morris et al. 2003; Lehto, Abes et al. 2010 ...Author: Wanling Liang, Jenny K. W. Lam
https://www.onlinelibrary.wiley.com/doi/abs/10.1002/adfm.201303188
A DNA Device that Mediates Selective Endosomal Escape and Intracellular Delivery of Drugs and Biologicals ... and a targeting capacity enough to overcome non‐specific pathways has not yet been achived. This study demonstrates that this is possible. ... NDs remain scattered throughout the cell, suggesting endosomal escape. This is confirmed in ...Author: Silvia Muro
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