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https://www.ncbi.nlm.nih.gov/pubmed/24730275
Endosomal escape: a bottleneck in intracellular delivery. Shete HK, Prabhu RH, Patravale VB. With advances in therapeutic science, apart from drugs, newer bioactive moieties like oligonucleotides, proteins, peptides, enzymes and antibodies are constantly being introduced for the betterment of therapeutic efficacy.Author: Harshad K. Shete, Rashmi H. Prabhu, Vandana B. Patravale
https://www.ingentaconnect.com/content/asp/jnn/2014/00000014/00000001/art00027
Jan 01, 2014 · The endosomal uptake pathway is known to be a rate-limiting barrier for such systems. Bioactive molecules get trapped in the endosomal vesicles and degraded in the lysosomal compartment, necessitating the need for effective strategies that facilitate the endosomal escape and enhance the cytosolic bioavailability of bioactives.
https://www.nature.com/articles/srep32301
Sep 08, 2016 · Previously, we had used the hemagglutinin (HA2) endosomal escape domain from influenza virus to enhance TAT-Cre protein delivery into cells 11. Likewise, two groups, Dr. Futaki’s in Japan and Dr. Norden’s in Sweden, have previously shown that addition of hydrophobic aromatic ring containing amino acids,...Author: Peter Lönn, Apollo D. Kacsinta, Xian-Shu Cui, Alexander S. Hamil, Manuel Kaulich, Khirud Gogoi, Stev...
https://www.researchgate.net/publication/261638527_Endosomal_Escape_A_Bottleneck_in_Intracellular_Delivery
On the other hand, progress in designing a novel smart polymeric carrier system that triggers endosomal escape by undergoing modulations in the intracellular milieu has further led to an improvement in intracellular delivery. These comprise pH, …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5015074/
Sep 08, 2016 · In conclusion, the TAT-EEDs described here show a significantly improved uptake profile compared to TAT alone and have potential to address the critical rate-limiting endosomal escape step in intracellular delivery of macromolecular biologic peptide, protein and siRNA therapeutics and to shape next-generation endosomal escape domains.Author: Peter Lönn, Apollo D. Kacsinta, Xian-Shu Cui, Alexander S. Hamil, Manuel Kaulich, Khirud Gogoi, Stev...
https://www.sciencedirect.com/science/article/abs/pii/S1748013214000565
Endosomal escape is a major bottleneck in cytosolic delivery of nanomaterials. Endosomal escape mechanisms are divided in pore formation, rupture and membrane fusion. Several assays are used to study endosomal escape mechanisms and efficiency.Author: Thomas F. Martens, Katrien Remaut, Jo Demeester, Stefaan C. De Smedt, Kevin Braeckmans
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