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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3276033/
In the intratracheal instillation, a small amount of drug solution or dispersion is delivered into the lungs by a special syringe. This provides a fast and quantifiable method of drug delivery to the lungs. The localized drug deposition is achieved with a comparatively small absorptive area.
https://www.ondrugdelivery.com/scaling-high-dose-delivery-lungs/
João Ventura Fernandes, Gonçalo Rebelo de Andrade and Peter Villax describe the scaling up of the currently marketed TwinCaps® inhaler into the new TwinMax™ design for high-dose delivery of challenging drug-alone formulations in single to short-term treatments and emergency situations.
http://www.pharmtech.com/four-challenges-pulmonary-drug-delivery
Sep 01, 2017 · Pulmonary drug delivery is becoming increasingly used. When developing pulmonary drugs, pharmaceutical chemists must consider drug absorption, control of particle size, suitable toxicology models, and patient compliance. The author reviews …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3424884/
Therefore, their use is rapidly expanding, especially for drug delivery to the lungs. Chitosan, one of the most famous and commonly used micelle, was recently used as nanoparticle to deliver drug to the lungs, especially for drugs with high first pass phenomena such as isoniazid.
https://www.ondrugdelivery.com/pulmonary-delivery-antimicrobial-peptides/
A particular advantage is the possibility for local drug delivery in the lung. The extension of using similar nanoformulation platforms for delivery of antimicrobial peptides holds promise for the future and is currently under development in FORMAMP.
https://onlinelibrary.wiley.com/doi/abs/10.1002/med.20140
The advent of nanotechnology has reignited interest in the lungs as a major route of drug delivery for both systemic and local treatments. The large surface area of the lungs …Author: Mark M. Bailey, Cory J. Berkland
https://www.liebertpub.com/doi/10.1089/jamp.2010.ab01
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https://www.researchgate.net/publication/230733979_The_lungs_and_drug_delivery
Pulmonary route of drug delivery gaining much importance in the present day research field as it enables to target the drug delivery directly to lung both for local and systemic treatment.
https://www.japsonline.com/admin/php/uploads/498_pdf.pdf
rapid removal of drug from the lungs or due to drug metabolism. Necessitates frequent dosing (Ozer, 2007). Uptake of inhaled drug after inhalation therapy There are several advantages in delivering drugs, to the lungs including a non invasive method of delivery; the surface area of the lung is between 80 m2 and 140 m2, which is about half the
https://www.liebertpub.com/doi/abs/10.1089/jamp.2010.ab01
Journal of Aerosol Medicine and Pulmonary Drug Delivery Vol. 23, No. 6 Abstracts from The Aerosol Society Drug Delivery to the Lungs 20 Edinburgh International Conference Centre Scotland, UK December 9–11, 2009
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