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https://www.ondrugdelivery.com/scaling-high-dose-delivery-lungs/
TwinCaps ® was launched in Japan in 2010, as part of Daiichi Sankyo’s Inavir ® drug product. Its simple use, effective delivery and ease of manufacture brought commercial success and Inavir became the best-selling drug in the Japanese influenza treatment market and TwinCaps ® the world’s third largest-selling unit-dose inhaler.. A NEW CHALLENGE
https://www.future-science.com/doi/full/10.4155/tde-2017-0037
Jul 21, 2017 · Presented at: Drug Delivery to the Lungs 27. Edinburgh, UK, 7–9 December 2016. Google Scholar; 48 Sanders M, Bruin R, Tran C. Overcoming differences in pMDI actuator resistance to create a standardised training tool. Presented at: Drug Delivery to the Lungs 26. Edinburgh, UK, 9–11 December 2015. Google ScholarAuthor: Stephen P Newman
https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/pulmonary-drug-delivery
Mohammed Ali, in Handbook of Non-Invasive Drug Delivery Systems, 2010. 9.6 Conclusions. During the past decade pulmonary drug delivery technology advanced substantially due to several inventions in propellants, excipients, and device technologies. The large surface area of the human lung, along with its rich blood supply, rapid onset of drug action with high bioavailability, and other ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3687239/
Effective drug delivery is essential in achieving improved therapeutic outcome when treating lung cancer. The integration of nanotechnology and pulmonary delivery of drug aerosols represents a new and exciting frontier for pharmaceutical dosage form design to increase the bioavailability and patient compliance, as supported by the results of ...
https://www.ondrugdelivery.com/pulmonary-delivery-antimicrobial-peptides/
Alternative nanoparticles for drug delivery are e.g., PLGA particles, alginate-chitosan hybrid particles, 5 and hyaluronan particles, 6 which all provide longer residence time in the lungs. 7,8 In general, studies using animal models have shown that the therapeutic index can be improved and the dose to reach the local MIC can be reduced when ...
https://www.slideshare.net/VenkateshPillala/drug-delivery-to-the-respiratory-system
Oct 22, 2013 · In the treatment of obstructive respiratory diseases, pulmonary delivery can minimize systemic side effects, provide rapid response and minimize the required dose since the drug is delivered directly to the conducting zone of the lungs . It is a needle free several techniques have been developed in the recent past, to improve the Quality of ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3146747/
Sep 01, 2010 · The limitations of micronized drug blends to deliver large doses of drug to the lungs was illustrated for aminoglycosides. (16,17) In these studies, 15–32 inhalations of micronized gentamicin were needed to deliver a therapeutic dose. Completing such a large number of inhalations is time consuming and not feasible in clinical practice.Author: David E. Geller, Jeffry Weers, Silvia Heuerding
https://www.materials-talks.com/blog/2010/11/26/drug-delivery-to-the-lungs-ddl-2010/
November 26th, 2010 By Anne Virden. Hello. My name is Anne Virden and I am ‘Product Technical Specialist Diffraction’ at Malvern Instruments. Laser diffraction is a key analytical tool in the development of inhaled pharmaceuticals, so I am really looking forward to attending this year’s Drug Delivery to the Lungs (DDL) 2010 conference and exhibition, where I’ll be working alongside ...
https://www.sciencedirect.com/science/article/pii/S0378517310001912
Controlled drug delivery systems have become increasingly attractive options for inhalation therapies. A large number of carrier systems have been developed and investigated as potential controlled drug delivery formulations to the lung, including drug-loaded lipid- and polymer-based particles (Zeng et al., 1995). As polymer degradation rates ...Author: Gabrielle Pilcer, Karim Amighi
https://www.meddeviceonline.com/doc/developing-a-smart-inhaler-for-optimal-drug-delivery-0001
Dec 16, 2019 · For instance, the drug delivery is typically completed in a continuous mode, independent of the patient’s inhalation/exhalation cycle. This leads to high dose variability and waste of drug into the air. Similarly, pressurized meter dose inhalers (pMDIs) are able to aerosolize the drug to sizes of between 2 µm and 4 µm. However, these ...
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