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https://www.sciencedirect.com/science/article/pii/S0896627302010541
The most direct approach to drug or gene delivery to all parts of the brain is the vascular route , and the transvascular brain drug delivery strategies include hyperosmolar BBB disruption, drug lipidization, protein cationization, and the chimeric peptide technology. Hyperosmolar BBB Disruption.Author: William M Pardridge
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2504014/
Jun 30, 2008 · 3.3.6. Gene delivery to the brain . Gene therapy could have significant potential in the treatment of various CNS diseases but the delivery into the brain is limited by the large size of the agents. It is likely that the focused ultrasound method could be used to deliver gene vectors through the BBB.Author: Kullervo Hynynen
https://www.ncbi.nlm.nih.gov/pubmed/18486271
Jun 30, 2008 · Ultrasound for drug and gene delivery to the brain. Hynynen K(1). Author information: (1)Department of Medical Biophysics, University of Toronto, Sunnybrook Health Sciences Centre, 2075 Bayview Ave, Toronto, ON, Canada. [email protected]: Kullervo Hynynen
https://bme.duke.edu/research/drug-gene-delivery
Important areas in this growing field include development of delivery vehicles such as plasmids, nanoparticles, viruses, liposomes, peptide/protein complexes, and biomaterial scaffolds, as well as studies of drug and gene transport, delivery strategies, delivery barriers, and …
https://www.nature.com/articles/nrd.2015.21
Jan 22, 2016 · From blood–brain barrier to blood–brain interface: new opportunities for CNS drug delivery William A. Banks 1 Nature Reviews Drug Discovery volume 15 , pages 275 – 292 ( 2016 ) Cite this articleAuthor: William A. Banks
https://www.sciencedirect.com/science/article/abs/pii/S0896627302010541
Brain drug development of either small molecule or large molecule (recombinant proteins, gene medicines) neurotherapeutics has been limited, owing to the restrictive transport properties of the brain microvasculature, which forms the blood-brain barrier (BBB) in vivo. Widespread drug delivery to the brain, while not feasible via craniotomy and intracerebral injection, is possible if the drug ...Author: William M Pardridge
http://jpet.aspetjournals.org/content/370/3/593
Sep 01, 2019 · Nose-to-Brain Mechanism of Delivery. For the purposes of drug delivery, the nasal cavity is divided into the respiratory area and the olfactory area, with the latter situated high up in the nares and the former closer to the nostrils (Sahin-Yilmaz and Naclerio, 2011).The nasal epithelium is well vascularized (Sahin-Yilmaz and Naclerio, 2011), and, within the olfactory area, olfactory neurons ...Author: Zian Wang, Guojun Xiong, Wai Chun Tsang, Andreas G. Schätzlein, Ijeoma F. Uchegbu
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