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https://www.sciencedirect.com/science/article/pii/S0896627302010541
The most direct approach to drug or gene delivery to all parts of the brain is the vascular route , and the transvascular brain drug delivery strategies include hyperosmolar BBB disruption, drug lipidization, protein cationization, and the chimeric peptide technology. Hyperosmolar BBB Disruption.Author: William M Pardridge
https://www.sciencedirect.com/science/article/abs/pii/S0896627302010541
Brain drug development of either small molecule or large molecule (recombinant proteins, gene medicines) neurotherapeutics has been limited, owing to the restrictive transport properties of the brain microvasculature, which forms the blood-brain barrier (BBB) in vivo. Widespread drug delivery to the brain, while not feasible via craniotomy and intracerebral injection, is possible if the drug ...Author: William M Pardridge
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2504014/
Jun 30, 2008 · 3.3.6. Gene delivery to the brain . Gene therapy could have significant potential in the treatment of various CNS diseases but the delivery into the brain is limited by the large size of the agents. It is likely that the focused ultrasound method could be used to deliver gene vectors through the BBB.Author: Kullervo Hynynen
https://www.researchgate.net/publication/11027469_Drug_and_Gene_Delivery_to_the_Brain
Drug and Gene Delivery to the Brain. ... brain via the transvascular route through the BBB. Novel brain drug delivery and drug targeting strategies can be developed from an understanding of the ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4199305/
Rational design of the drug delivery systems (e.g., selection of optimal geometry and affinity to specific epitopes) provides an unprecedented level of control of such parameters of drug delivery as pharmacokinetics, circulation in blood, binding to selected endothelial cell phenotypes, anchoring on cell surface or internalization into the ...Author: Muzykantov, Muro S
https://core.ac.uk/display/82405713
Drug and Gene Delivery to the Brain The Vascular Route . ... is possible if the drug is delivered to brain via the transvascular route through the BBB. Novel brain drug delivery and drug targeting strategies can be developed from an understanding of the molecular and cellular biology of the brain microvascular and BBB transport processesAuthor: William M Pardridge
https://www.hindawi.com/journals/bmri/2014/869269/
Therefore, targeted molecular based therapies are developed for treatment of brain tumors that could deliver the antitumor drugs to the target sites and stop aberrant signaling pathways in the brain. Further, vascular route should be improved to make it more promising for drug delivery to the brain because it allows a widespread diffusion of ...Author: Ravi Kant Upadhyay
https://bme.duke.edu/research/drug-gene-delivery
Important areas in this growing field include development of delivery vehicles such as plasmids, nanoparticles, viruses, liposomes, peptide/protein complexes, and biomaterial scaffolds, as well as studies of drug and gene transport, delivery strategies, delivery barriers, and …
https://www.pharmatutor.org/pdf_download/pdf/Vol.%203,%20Issue%208,%20August%202015,%20PharmaTutor,%20Paper-3.pdf
Drug targeting is the delivery of drugs to receptors or organs or any other specific part of the body to which one wishes to deliver the drugs exclusively. In this review article we are try to highlight how the nanoparticle work in blood brain barrier as a targeting drug delivery system.[3] ANATOMY OF BLOOD BRAIN BARRIER [4, 5]
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