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https://www.drugtargetreview.com/news/36234/deliver-blood-brain/
Oct 19, 2018 · Current therapies in clinical trials often fail due to the difficulty involved in getting enough of the drug through the blood-brain barrier to the brain to show the effectiveness of the drug. The complex system of the blood-brain barrier, consisting of molecular gateways, tightly control what enters and exits the brain.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3494002/
Aug 29, 2012 · Drug transport across the blood–brain barrier. William M Pardridge 1 ... Small molecule drug permeation through lipid membranes demonstrates an ... Pardridge WM. Epidermal growth factor radiopharmaceuticals: 111In chelation, conjugation to a blood-brain barrier delivery vector via a biotin-polyethylene linker, pharmacokinetics, and in vivo ...Author: William M Pardridge
https://www.sciencedirect.com/science/article/pii/S0169409X11002900
5.2. Transport system-mediated drug delivery across the blood–brain barrier. The combination of endogenous transport systems present in the BBB and macromolecular conjugates or surface enhanced nano-particulate delivery systems such as liposomes, nanoparticles and supermolecular complexes has been utilised to access the brain.Author: Yan Chen, Lihong Liu
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4127280/
Jul 20, 2014 · Therefore, for successful delivery of drugs, blood brain barrier disruption or opening is done by ultrasound and largely used as intra-arterial infusion therapy. It allows both the chemotherapeutic agents and antibodies to enter through blood brain barrier . Hence, BBB dysfunction could be of great therapeutic value in conditions in which ...Author: Ravi Kant Upadhyay
https://www.sciencedirect.com/science/article/pii/S0168365916303236
Nanoparticle-mediated brain drug delivery: Overcoming blood–brain barrier to treat neurodegenerative diseases. ... R. PopovtzerTransport of nanoparticles through the blood–brain barrier for imaging and therapeutic applications. Nanoscale, 6 (2014), pp. 2146-2152, 10.1039/c3nr04878k. Google ScholarAuthor: Cláudia Saraiva, Catarina Praça, Raquel Ferreira, Tiago Santos, Lino Ferreira, Liliana Bernardino
https://www.medscape.com/viewarticle/770396
Nov 06, 2019 · Nanotechnology may be the key to opening the gate of the blood brain-barrier, providing a significant advantage over currently used drug delivery strategies for …
https://www.technologynetworks.com/neuroscience/news/drug-delivery-device-buzzes-through-the-blood-brain-barrier-328936
Drug Delivery Device Buzzes Through the Blood-Brain Barrier. News Jan 06, 2020 ... Blood vessels in the brain are lined by cells fitted together tightly, forming a so-called blood-brain barrier, which walls off bacteria and toxins from the brain itself. But that blood-brain barrier also blocks medication for brain diseases such as cancer.
https://link.springer.com/article/10.1007%2Fs40263-016-0405-9
Jan 18, 2017 · CNS disorders are on the rise despite advancements in our understanding of their pathophysiological mechanisms. A major hurdle to the treatment of these disorders is the blood–brain barrier (BBB), which serves as an arduous janitor to protect the brain. Many drugs are being discovered for CNS disorders, which, however fail to enter the market because of their inability to cross the BBB. …Author: Mayur M. Patel, Bhoomika M. Patel
https://www.nature.com/articles/nrd.2015.21
Jan 22, 2016 · From blood–brain barrier to blood–brain interface: new opportunities for CNS drug delivery William A. Banks 1 Nature Reviews Drug Discovery volume 15 , pages 275 – 292 ( 2016 ) Cite this articleAuthor: William A. Banks
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