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https://www.drugtargetreview.com/news/36234/deliver-blood-brain/
Oct 19, 2018 · Drug delivery through the blood-brain barrier has shown to be difficult to overcome, but researchers may have discovered a method to overcome this issue… Research on the delivery of therapeutics to the brain could have implications for the treatment of a wide range of diseases, such as Alzheimer’s, ALS, brain cancer and Parkinson’s.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3494002/
Aug 29, 2012 · The BBB is the principal interface between blood and the ISF that bathes synaptic connections within the parenchyma of the brain. A separate barrier system in the brain is localized to the epithelial cells of the choroid plexus, which form the blood–cerebrospinal fluid (CSF) barrier (BCSFB).Author: William M Pardridge
https://www.ncbi.nlm.nih.gov/pubmed/27020469
Author information: (1)a Brain Research Institute , University of California , Los Angeles , CA , USA. INTRODUCTION: There are 2 misconceptions about the cerebrospinal fluid (CSF), the blood-brain barrier (BBB), and brain drug delivery, which date back to the discovery of a barrier between blood and brain over 100 years ago.Author: William M. Pardridge
https://www.sciencedirect.com/science/article/pii/S0169409X11002900
5.2. Transport system-mediated drug delivery across the blood–brain barrier. The combination of endogenous transport systems present in the BBB and macromolecular conjugates or surface enhanced nano-particulate delivery systems such as liposomes, nanoparticles and supermolecular complexes has been utilised to access the brain.Author: Yan Chen, Lihong Liu
https://www.hindawi.com/journals/bmri/2014/869269/
Therefore, for successful delivery of drugs, blood brain barrier disruption or opening is done by ultrasound and largely used as intra-arterial infusion therapy. It allows both the chemotherapeutic agents and antibodies to enter through blood brain barrier . Hence, BBB dysfunction could be of great therapeutic value in conditions in which ...Author: Ravi Kant Upadhyay
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