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https://www.onlinelibrary.wiley.com/doi/abs/10.1002/wnan.147
The delivery of drugs through the skin provides a convenient route of administration that is often preferable to injection because it is noninvasive and can typically be self‐administered. These two factors alone result in a significant reduction of medical complications and improvement in patient compliance.Author: J. Torin Huzil, Siv Sivaloganathan, Mohammad Kohandel, Marianna Foldvari
https://www.tandfonline.com/doi/pdf/10.1586/edm.12.32
If the skin is to be used as a route of topical drug delivery, the barrier must be overcome, but this can normally only be achieved with small, relatively lipophilic molecules.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2700785/
Already, cavitational ultrasound has been approved for enhanced delivery of lidocaine through the skin 43 and has been studied extensively in animals for delivery of insulin, as well as heparin, tetanus toxoid vaccine and other compounds 41. Ultrasound can be applied …Author: Mark R Prausnitz, Robert Langer
http://sustainable-nano.com/2016/09/21/dermal-drug-delivery/
Sep 21, 2016 · The drug delivery component uses the electrical response as a heater to melt polymer microneedles loaded with the diabetes drug for delivery into the patient’s skin. 4,6 In essence, when a patient’s glucose concentration changes, drug is delivered accordingly.
https://www.youtube.com/watch?v=4FBmM-d7h64
Feb 25, 2019 · Medherants is innovating with their new technology which will deliver drugs to the user through their skin. The drug is mixed with the adhesive and when attached to the skin will diffuse into the ...Author: Innovate UK
https://www.thebodypro.com/article/drug-delivery-strategies
Jul 01, 2004 · Another form of transdermal drug delivery includes devices that use air pressure to inject a small stream of medicine through the top layers of the skin. Air pressure guns have been used for several years to give vaccines to children.
https://www.researchgate.net/publication/276837593_The_Structure_of_Skin_and_Transdermal_Drug_Delivery_System-A_Review
The major challenge in designing transdermal drug delivery systems is to overcome the natural transport barrier of the skin. One approach is the use of vesicle formulations.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4695828/
Oct 22, 2015 · As a novel and minimally invasive approach, MN are capable of creating superficial pathways across the skin for small drugs, macromolecules, nanoparticles, or fluid extractions to achieve enhanced transdermal drug delivery .Their sharp tips are short enough to limit contact with skin nerves, thus preventing pain sensation and they are narrow enough to induce minimal trauma and reduce the …Author: Ahlam Zaid Alkilani, Maelíosa T.C. McCrudden, Ryan F. Donnelly
http://drugdelivery.chbe.gatech.edu/Papers/2012/Prausnitz%20Derm%20Book%20Chapter%202012.pdf
Skin Barrier and Transdermal Drug Delivery systemic infl uences, it can be regulated by external infl uences, i.e. changes in the status of the permeability barrier 17. Acute perturbations of the permeability barrier stimulate a characteristic recovery sequence that leads to restoration of normal function over about 72 hours inFile Size: 1MB
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