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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2700785/
Transdermal delivery represents an attractive alternative to oral delivery of drugs and is poised to provide an alternative to hypodermic injection too 1 – 4.For thousands of years, people have placed substances on the skin for therapeutic effects and, in the modern era, a variety of topical formulations have been developed to treat local indications.Author: Mark R Prausnitz, Robert Langer
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4695828/
Oct 22, 2015 · 2. Transdermal Drug Delivery (TDD) TDD is a painless method of delivering drugs systemically by applying a drug formulation onto intact and healthy skin [2,5].The drug initially penetrates through the stratum corneum and then passes through the deeper epidermis and dermis without drug accumulation in the dermal layer.Author: Ahlam Zaid Alkilani, Maelíosa T.C. McCrudden, Ryan F. Donnelly
http://sustainable-nano.com/2016/09/21/dermal-drug-delivery/
Sep 21, 2016 · Dermal drug delivery can be much more convenient than pills or injections. (image by RegBarc) Although dermal drug delivery seems to be an ideal method for patients, designing drugs that are capable of being delivered through the skin is difficult. After all, one of the purposes of skin is to limit molecules from entering the body.
https://metrology.imedpub.com/transdermal-drug-delivery-tdd-throughskin-patches.php?aid=9340
May 16, 2016 · Transdermal Drug Delivery (TDD) through Skin Patches Natali R Gendelberg, Roberto Falcone and Nuggehalli M Ravindra * Interdisciplinary Program in Materials Science & Engineering, New Jersey Institute of Technology, Newark, NJ, USAAuthor: Natali R Gendelberg, Roberto Falcone, Nuggehalli M Ravindra
https://www.frontiersin.org/articles/10.3389/fbioe.2018.00015/full
To treat systemic medical conditions as well as localized problems such as joint or muscle concerns, transdermal delivery systems (TDDS), which use the skin as the main route of drug delivery, are very appealing. Over the years, these systems have shown to offer important advantages over oral as well as intravenous drug delivery routes.Author: Sabine Szunerits, Rabah Boukherroub
http://drugdelivery.chbe.gatech.edu/Papers/2012/Prausnitz%20Derm%20Book%20Chapter%202012.pdf
Skin Barrier and Transdermal Drug Delivery systemic infl uences, it can be regulated by external infl uences, i.e. changes in the status of the permeability barrier 17. Acute perturbations of the permeability barrier stimulate a characteristic recovery sequence that leads to restoration of normal function over about 72 hours inFile Size: 1MB
https://www.onlinelibrary.wiley.com/doi/abs/10.1002/wnan.147
Drug delivery through the skin: molecular simulations of barrier lipids to design more effective noninvasive dermal and transdermal delivery systems for small molecules, biologics, and cosmetics. J. Torin Huzil. School of Pharmacy, University of Waterloo, Waterloo, Ontario, Canada.Author: J. Torin Huzil, Siv Sivaloganathan, Mohammad Kohandel, Marianna Foldvari
https://www.thebodypro.com/article/drug-delivery-strategies
Jul 01, 2004 · Drug Delivery and HIV. There are currently limitations to the technologies described above, particularly with regard to current anti-HIV drugs. Most are made of molecules too large to pass easily through the skin or mucous membranes.
http://ijpsr.com/bft-article/transdermal-drug-delivery-system-a-review/?view=fulltext
1 Transdermal Drug Delivery System (TDDS) are defined as self contained, discrete dosage forms which are also known as “patches” 2, 3 when patches are applied to the intact skin, deliver the drug through the skin at a controlled rate to the systemic circulation.
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