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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3885379/
Jan 08, 2014 · Glutathione pegylated liposomal doxorubicin (2B3-101) is being developed as a new treatment option for patients with brain cancer. It is based on already marketed pegylated liposomal doxorubicin (Doxil®/Caelyx®), with an additional glutathione coating …Author: Pieter J. Gaillard, Chantal C. M. Appeldoorn, Rick Dorland, Joan van Kregten, Francesca Manca, Danie...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4822833/
Specifically, this study sought to evaluate the safety and efficacy of EGFR targeted, doxorubicin loaded minicells (designated EGFR minicells Dox) to deliver doxorubicin to spontaneous brain tumors in 17 companion dogs; a comparative oncology model of human brain cancers.Author: Jennifer A. MacDiarmid, Veronika Langova, Dale Bailey, Scott T. Pattison, Stacey L. Pattison, Neil C...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1635000/
Local delivery of carmustine (BCNU) via biodegradable polymers has been shown to improve survival in patients with glioblastoma multiforme (GBM). In the current study, we hypothesized that local delivery of an anthracycline antibiotic, doxorubicin (DOX), might act to improve the survival of animals bearing experimental intracranial glioma.Author: Maciej S. Lesniak, Urvashi Upadhyay, Rory Goodwin, Betty Mae Tyler, Henry Brem
https://www.sciencedirect.com/science/article/pii/S0022354915305074
Glutathione PEGylated liposomal doxorubicin (2B3-101) has been developed to safely enhance the delivery of doxorubicin to brain tumors. However, doxorubicin concentration in extracellular brain fluid cannot yet be reliably measured using conventional techniques. Cerebral …Author: Thomas Birngruber, Reingard Raml, Werner Gladdines, Christina Gatschelhofer, Edgar Gander, Arijit Gh...
https://pubs.acs.org/doi/abs/10.1021/acs.molpharmaceut.7b00341
Herein, we demonstrate a straightforward strategy for brain targeting by encapsulating doxorubicin (DOX) into a naturally available and unmodified apoferritin nanocage (DOX-loaded APO). APO can specifically bind to cells expressing transferrin receptor 1 (TfR1).Author: Zhijiang Chen, Meifang Zhai, Xiang Yang Xie, Yue Zhang, Siyu Ma, Zhiping Li, Fanglin Yu, Baoquan Zha...
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0082331
Overall, these data demonstrate that glutathione pegylated liposomal doxorubicin enhances the effective delivery of doxorubicin to brain tumors and could become a promising new therapeutic option for the treatment of brain malignancies.Author: Pieter J. Gaillard, Chantal C. M. Appeldoorn, Rick Dorland, Joan van Kregten, Francesca Manca, Danie...
https://www.researchgate.net/publication/262110298_Enhanced_Doxorubicin_Delivery_to_the_Brain_Administered_Through_Glutathione_PEGylated_Liposomal_Doxorubicin_2B3-101_as_Compared_with_Generic_CaelyxRDoxil_R_A_Cerebral_Open_Flow_Microperfusion_Pilot_St
Glutathione PEGylated liposomal doxorubicin (2B3-101) has been developed to safely enhance the delivery of doxorubicin to brain tumors. However, doxorubicin concentration in extracellular brain...
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