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https://link.springer.com/chapter/10.1007/128_2007_12
Nov 24, 2007 · A third class of conjugates has been designed for receptor-mediated targeted delivery,including folate, somatostatin, bombesin, LHRH receptors or integrin and lectin. Transportation of doxorubicin with peptide vectors has been simultaneously investigated to overcomethe problem of penetration in the brain or the problem of multidrug resistance.Author: Jean-Claude Florent, Claude Monneret
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6944323/
Introduction. ADCs are an emerging class of targeted anticancer drug delivery agent that confer selective and sustained cytotoxic drug delivery to tumors [].An ADC can be divided into three main structural units (Figure 1a): the Ab; the cytotoxic agent; and the linker.Selecting a high-affinity Ab, stable linker, and potent cytotoxic payload enables the novel development of safe and efficient ...Author: Samaresh Sau, Hashem O. Alsaab, Hashem O. Alsaab, Sushil Kumar Kashaw, Sushil Kumar Kashaw, Katyayan...
https://www.sciencedirect.com/science/article/pii/S0168365916305120
Selective delivery of doxorubicin by novel stimuli-sensitive nano-ferritins overcomes tumor refractoriness. ... H. Wunderli-Allenspach, F. KratzDifferences in the intracellular distribution of acid-sensitive doxorubicin-protein conjugates in comparison to free and liposomal formulated doxorubicin as shown by confocal microscopy. (vol 18, pg 29 ...Author: Giulio Fracasso, Elisabetta Falvo, Gianni Colotti, Francesco Fazi, Tiziano Ingegnere, Adriana Amalfi...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406713/
Feb 16, 2019 · The rationale of performing NIR-imaging with PDL1-S0456 is due to its significant advantage as a (i) tumor image guided surgery tool in the clinic, and to (ii) understanding tumor selective delivery, tumor retention, and safety to predict therapeutic outcome in different tumor models.Author: Samaresh Sau, Alex Petrovici, Hashem O. Alsaab, Ketki Bhise, Arun K. Iyer
https://www.researchgate.net/publication/11864449_Selective_tumor_sensitization_to_taxanes_with_the_MAB-drug_conjugate_CBR96-doxorubicin
Selective tumor sensitization to taxanes with the MAB-drug conjugate CBR96-doxorubicin ... In heterogeneous brain tumors, enhanced delivery of BR96-DOX …
https://www.researchgate.net/publication/306088929_Selective_delivery_of_doxorubicin_by_novel_stimuli-sensitive_nano-ferritins_overcomes_tumor_refractivity
Selective delivery of doxorubicin by novel stimuli-sensitive nano-ferritins overcomes tumor refractivity Article in Journal of Controlled Release 239 · August 2016 with 157 Reads
https://pubs.acs.org/doi/10.1021/jm020149g
Aug 14, 2002 · High mole ratio BR96 immunoconjugates were synthesized using branched peptide−doxorubicin linkers designed to liberate doxorubicin following antigen-specific internalization into lysosomes. However, these immunoconjugates are highly prone to noncovalent, dimeric aggregation. We hypothesize that this is due to (1) the hydrophobic nature of the peptides, (2) the loss of positive …Author: H. Dalton King, Gene M. Dubowchik, Harold Mastalerz, David Willner, Sandra J. Hofstead, Raymond A. F...
https://www.sciencedirect.com/science/article/pii/S0142961213015901
After entering the cell, the peptide-conjugated 25 nm GNS accumulated around the cell nucleus. High cell selectivity by α-helical CPP sequences was also demonstrated. Our results indicate that these α-helical peptide and 25 nm GNS conjugates are useful elements in an efficient cell-selective drug delivery system.Author: Hyejin Park, Hiroshi Tsutsumi, Hisakazu Mihara
https://pubs.acs.org/doi/10.1021/mp100185f
Sep 21, 2010 · Targeting Groups Employed in Selective Dendrons and Dendrimers. Pharmaceutics ... dendrimer-poly(ethylene glycol) conjugates for intracellular delivery of doxorubicin. Acta Biomaterialia 2016, 36, 241-253. DOI: 10.1016/j.actbio.2016.03.027. ... Targeted delivery of doxorubicin to human breast cancers by folate-decorated star-shaped PEG–PCL ...Author: Liang Han, Rongqin Huang, Shuhuan Liu, Shixian Huang, Chen Jiang
https://onlinelibrary.wiley.com/doi/full/10.1002/psc.3135
Nov 22, 2018 · Overexpression of gonadotropin‐releasing hormone (GnRH) receptor in many tumors but not in normal tissues makes it possible to use GnRH analogs as targeting peptides for selective delivery of cytotoxic agents, which may help to enhance the uptake of anticancer drugs by cancer cells and reduce toxicity to normal cells.Author: Songtao Li, Hongling Zhao, Xiaomin Chang, Jianping Wang, Enhong Zhao, Zhifeng Yin, Xiaoxia Mao, Shuh...
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