Dox Drug Delivery

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Doxorubicin-loaded platelets as a smart drug delivery ...

    https://www.nature.com/articles/srep42632
    Feb 15, 2017 · Doxorubicin-loaded platelets as a smart drug delivery system: An improved therapy for lymphomaAuthor: Peipei Xu, Huaqin Zuo, Bing Chen, Ruju Wang, Arsalan Ahmed, Yong Hu, Jian Ouyang

Co-delivery of doxorubicin and ... - PubMed Central (PMC)

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4753416/
    Feb 15, 2016 · Ample attention has focused on cancer drug delivery via prodrug nanoparticles due to their high drug loading property and comparatively lower side effects. In this study, we designed a PEG-DOX-Cur prodrug nanoparticle for simultaneous delivery of doxorubicin (DOX) and curcumin (Cur) as a combination therapy to treat cancer.Author: Yumin Zhang, Cuihong Yang, Weiwei Wang, Jinjian Liu, Qiang Liu, Fan Huang, Liping Chu, Honglin Gao, ...

Tumor-targeted and pH-controlled delivery of doxorubicin ...

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4631428/
    Oct 29, 2015 · To achieve this goal, we have developed and tested a multifunctional TfR-targeted GNR drug delivery system that efficiently carries and releases Dox under acid-labile conditions (GNR-Dox-Tf-NP), such as the acidic environment present in the intracellular endosomal compartment and under hypoxic conditions. 40 Physicochemical studies revealed that the GNR-Dox-Tf nanoparticles were …Author: Narsireddy Amreddy, Ranganayaki Muralidharan, Anish Babu, Meghna Mehta, Elyse V Johnson, Yan D Zhao,...

A doxorubicin delivery platform using engineered natural ...

    https://www.sciencedirect.com/science/article/pii/S014296121301449X
    Targeted drug delivery vehicles with low immunogenicity and toxicity are needed for cancer therapy. Here we show that exosomes, endogenous nano-sized membrane vesicles secreted by most cell types, can deliver chemotherapeutics such as doxorubicin (Dox) to tumor tissue in BALB/c nude mice.Author: Yanhua Tian, Suping Li, Jian Song, Tianjiao Ji, Motao Zhu, Gregory J. Anderson, Jingyan Wei, Guangju...

Drug Delivery Vehicle - an overview ScienceDirect Topics

    https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/drug-delivery-vehicle
    Drug delivery to the tumor cells: Niosomal delivery of several anticancer drugs were shown to bypass their side effects due to successful delivery to the diseased tissues. Examples include doxorubicin, which usually shows cardiotoxicity depending upon the dose.

Doxorubicin-loaded environmentally friendly carbon dots as ...

    https://www.sciencedirect.com/science/article/pii/S0927776517304435
    The CDs were complexed with doxorubicin (DOX) with a view to targeted drug delivery. The CD-DOX complexes displayed pH-dependent DOX release behavior. Compared to free DOX, CD-DOX complexes were significantly more deadly to cancer cells. Increased efficacy was based on localized drug release in the nuclei of cancer cells.Author: Yifang Yuan, Bin Guo, Liying Hao, Na Liu, Yunfeng Lin, Wushuang Guo, Xiaoguang Li, Bin Gu

ZnO–DOX@ZIF-8 Core–Shell Nanoparticles for pH-Responsive ...

    https://pubs.acs.org/doi/abs/10.1021/acsbiomaterials.7b00435
    The core–shell nanoparticles exhibit good dispersibility and stability as well as pH-responsive drug release property. While only up to 20% of loaded DOX was released in the buffer of pH 7.4, over 80% of DOX was released in the buffer of pH 5.5 because of the decomposition of the ZIF-8 shell as well as the dissolution of the ZnO co...Author: Cunchuan Zheng, Yang Wang, Soo Zeng Fiona Phua, Wei Qi Lim, Yanli Zhao

Drug affinity and targeted delivery: double ...

    https://jnanobiotechnology.biomedcentral.com/articles/10.1186/s12951-020-00609-2
    The optimal drug delivery system should be biocompatible, biodegradable, and allow the sustained release of the drug only after it reaches the target cells. Silk, as a natural polymer, is a great candidate for building drug carriers. Genetically engineered silks offer the possibility of functionalization.

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