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http://www.biopharminternational.com/dna-vaccine-delivery
Oct 02, 2011 · DNA Vaccine Delivery. Development of the ideal DNA vaccine requires the optimization of delivery strategies and plasmid vectors. A DNA vaccine is a plasmid produced in Escherichia coli that contains an antigen gene controlled by a promoter that functions only in animal cells, usually the cytomegalovirus promoter.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274812/
Nov 15, 2018 · More recently, the DNA vaccine delivery properties of orally applied bacteria, for example with regard to phagolysosomal escape have been improved by additional coating with NC . Compared with other sytemic routes of DNA vaccination, pulmonary application of aerolized DNA vaccines is a rather new approach [ 230 ].Author: Dominika Hobernik, Matthias Bros
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3109217/
Electroporation Enhanced DNA Vaccine Delivery. Electroporation (EP) is a method to introduce macromolecules such as nucleic acids into cells, either in vivo or in vitro, via the application of brief electric pulses to induce transient and reversible permeabilization of the cell membrane (Figure 1).Author: Niranjan Y Sardesai, David B Weiner
https://pubs.acs.org/doi/10.1021/acs.molpharmaceut.0c00054
A DNA Vaccine Delivery Platform Based on Elastin-Like Recombinamer Nanosystems for Rift Valley Fever Virus Molecular Pharmaceutics This work analyzes the immunogenicity of six genetically engineered constructs based on elastin-like recombinamers (ELRs) fused to the Gn glycoprotein from Rift Valley fever virus (RVFV).
https://www.researchgate.net/publication/309905181_DNA_Vaccine_Delivery_and_Improved_Immunogenicity
The perfor- mance of DNA vaccines can be significantly improved by better gene delivery with more cells (including immune cells) presenting immunogen to the immune system of the host 101, 102 . We tested different delivery vehicles, com- paring an ordinary 29G-needle insulin syringe, microneedles, and a CO 2 -driven Biojector. ...
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