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https://link.springer.com/chapter/10.1007%2F978-1-4614-0881-9_6
Sep 27, 2011 · Abstract. This chapter presents an overview on the different types of drug delivery systems that are predominantly governed by diffusion. The systems are classified according to their physical structure (reservoir devices versus monolithic systems), as well as according to the ratio of “initial drug loading and drug solubility.” For various cases,...Author: Juergen Siepmann, Ronald A. Siegel, Florence Siepmann
http://www.demonstrations.wolfram.com/DiffusionControlledDrugDelivery/
Diffusion-Controlled Drug Delivery. This Demonstration models a diffusion-controlled drug delivery system to determine the amount of an active pharmaceutical ingredient (API) released from a polymer sphere as a function of time. The elapsed time is limited to 20 hours to …
https://www.sciencedirect.com/science/article/pii/S0168365999000930
Diffusion is the most important mechanism used to control drug release from pharmaceutical devices. As previously described, the resulting release kinetics essentially depend on the size and shape of the dosage form. Desired release profiles can be achieved by adjusting the geometry and the dimensions of the system.Author: J Siepmann, F Lecomte, R Bodmeier
https://www.hansvanlaarhoven.nl/diffusion-based-delivery/
The drug delivery from a diffusion based delivery system can be simulated using the transport of diluted species module in Comsol Multiphysics™.
https://www.researchgate.net/publication/278662176_Diffusion_Controlled_Drug_Delivery_Systems
Reservoir systems (drug-loaded core surrounded by drug-free membrane) provide long-term controlled drug release. This is especially beneficial for drug delivery to specific body regions including ...
https://www.sciencedirect.com/science/article/pii/S0168365911009588
For each type of drug delivery system and type of release conditions the given, so-called “initial and boundary” conditions need to be considered. The “initial conditions” concern the initial distribution of the diffusing species in the system.Author: Juergen Siepmann, Juergen Siepmann, Florence Siepmann, Florence Siepmann
http://www.thepharmajournal.com/vol1Issue10/Issue_dec_2012/3.1.pdf
Diffusion controlled release7 Reservoir type devices Matrix type devices 3. Diffusion and Dissolution controlled systems Ion exchange resins 5. ½ of a drug the larger will be the fluctuations between the maximum steady state concentration and maximum steady state concentration upon repetitive dosing.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2846103/
A current trend in the controlled drug delivery field is the development of multi-component material systems, i.e. integrating multiple materials with diverse physicochemical properties. For instance, semi-interpenetrating networks composed of crosslinked, stable PEG matrices and biodegradable labile gelatin macromolecules have shown to be effective drug delivery matrices and tissue scaffold for wound …Author: Yao Fu, Weiyuan John Kao
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