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https://link.springer.com/chapter/10.1007%2F978-1-4614-0881-9_6
Sep 27, 2011 · Abstract. This chapter presents an overview on the different types of drug delivery systems that are predominantly governed by diffusion. The systems are classified according to their physical structure (reservoir devices versus monolithic systems), as well as according to the ratio of “initial drug loading and drug solubility.” For various cases,...Author: Juergen Siepmann, Ronald A. Siegel, Florence Siepmann
https://www.pharmacologicalsciences.us/elderly-patients/diffusioncontrolled-drug-delivery-systems.html
Diffusion is one of the basic mass transport mechanisms, which is involved in the control of drug release from numerous drug delivery systems (14-16). Fick was the first to treat this phenomenon in a quantitative way (21), and the textbook of Crank (22) provides various solutions of Fick's second law for different device geometries and initial and boundary conditions.
http://www.demonstrations.wolfram.com/DiffusionControlledDrugDelivery/
Diffusion-Controlled Drug Delivery. This Demonstration models a diffusion-controlled drug delivery system to determine the amount of an active pharmaceutical ingredient (API) released from a polymer sphere as a function of time. The elapsed time is limited to 20 hours to …
https://www.sciencedirect.com/science/article/pii/S0168365999000930
The aim of this study was to investigate the effect of the composition (type and amount of plasticizer, type of polymer) of a diffusion-controlled drug delivery system (monolithic solution) on the diffusivity of a drug quantitatively.Author: J Siepmann, F Lecomte, R Bodmeier
https://www.researchgate.net/publication/278662176_Diffusion_Controlled_Drug_Delivery_Systems
Reservoir systems (drug-loaded core surrounded by drug-free membrane) provide long-term controlled drug release. This is especially beneficial for drug delivery to specific body regions including ...
https://www.slideshare.net/biswajitmaity5895/diffusion-controlled-systems-solventactivated-system-chemically-controlled-system-73850924
Mar 29, 2017 · DIFFUSION-CONTROLLED SYSTEMS INVOLVE RESERVOIR AND MATRIX • A reservoir is generally spherical, cylindrical, or disc-like in shape and consists of a drug core in powdered or liquid form. • A layer of non-bio-degradable polymeric material, through which the drug slowly diffuses, surrounds the core.
https://www.hansvanlaarhoven.nl/reservoir-system/
In a reservoir system the drug is either molecular dissolved or dispersed in a reservoir that is surrounded by a rate limiting inert membrane. In a monolithic or matrix device this membrane is absent. Although controlled delivery from a monolithic device is very well possible, the presence of a membrane normally provides for a better release profile.
http://www.thepharmajournal.com/vol1Issue10/Issue_dec_2012/3.1.pdf
2. Diffusion controlled release7 Reservoir type devices Matrix type devices 3. Diffusion and Dissolution controlled systems Ion exchange resins 5. Osmotically controlled release BIOPHARMACEUTIC AND PHARMACOKINETIC ASPECTS IN THE DESIGN OF CONTROLLED RELEASE PER ORAL DRUG DELIVERY SYSTEMS Controlled release drug delivery systems9, 21 are
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2846103/
Environmentally sensitive polymeric delivery systems are designed to achieve targeted delivery and controlled release in vivo upon specific stimuli, such as pH, ionic strength, enzyme-substrate, magnetic, thermal, electrical, ultrasound, etc . Drug release from pH- and enzyme-sensitive polymeric delivery systems is mainly attributed to stimuli-triggered degradation.Author: Yao Fu, Weiyuan John Kao
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