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http://www.thepharmajournal.com/vol1Issue10/Issue_dec_2012/3.1.pdf
Diffusion controlled release7 Reservoir type devices Matrix type devices 3. Diffusion and Dissolution controlled systems Ion exchange resins 5. ½ of a drug the larger will be the fluctuations between the maximum steady state concentration and maximum steady state concentration upon repetitive dosing.
https://www.sciencedirect.com/science/article/pii/S0168365999000930
An effective tool to modify the drug release kinetics from diffusion-controlled delivery systems is to vary the relative amount of plasticizer. Fig. 4A shows the significant influence of the TBC level (ranging from 10.0 to 40.0% w/w, 2.5% w/w increments) on the diffusion coefficient of …Author: J Siepmann, F Lecomte, R Bodmeier
https://www.sciencedirect.com/science/article/pii/S0376738806001517
A new approach for treating dissolution-diffusion controlled drug release from planar polymeric systems with any spatial variation in the initial drug loading and in the drug particle size distribution …Author: María I. Cabrera, Julio A. Luna, Ricardo J.A. Grau
https://www.hansvanlaarhoven.nl/diffusion-based-delivery/
The drug delivery from a diffusion based delivery system can be simulated using the transport of diluted species module in Comsol Multiphysics™.
https://www.slideshare.net/ganapati123/oral-dissolution-controlled-release-system
Mar 18, 2013 · DIFFUSION AND DISSOLUTION CONTROLLED SYSTEM• The main feature of this system is that the drug core is enclosed with a partially soluble membrane. drug Partially Soluble membrane Pores produced by soluble portion of Polymer membrane 19.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2846103/
A current trend in the controlled drug delivery field is the development of multi-component material systems, i.e. integrating multiple materials with diverse physicochemical properties. For instance, semi-interpenetrating networks composed of crosslinked, stable PEG matrices and biodegradable labile gelatin macromolecules have shown to be effective drug delivery matrices and tissue scaffold for wound …Author: Yao Fu, Weiyuan John Kao
http://www.kinampark.com/T-DrugDel/files/9.%20Mechanisms%20of%20Controlled%20Release.pdf
core or polymeric matrix containing the drug. Since the dissolution of polymeric materials is the key to this mechanism, all the polymers used A Table 9.1 Mechanisms of Controlled Drug Release Physical Mechanisms Dissolution Encapsulated dissolution system (Reservoir system) Matrix dissolution system Diffusion Reservoir device Nonporous ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4142099/
Sep 28, 2014 · The controlled drug delivery technology has progressed over the last six decades. It began in 1952 with the introduction of the first sustained release formulation. The 1st generation (1950-1980) of drug delivery was focused on developing oral and transdermal sustained release systems and establishing the controlled drug release mechanisms.Author: Kinam Park
https://link.springer.com/chapter/10.1007%2F978-1-4614-0881-9_6
Sep 27, 2011 · This chapter presents an overview on the different types of drug delivery systems that are predominantly governed by diffusion. ... the applicability of the presented theories and the benefits of understanding how a diffusion-controlled drug delivery system works. ... of drug release from planar matrix systems: effects of a finite dissolution rate.Author: Juergen Siepmann, Ronald A. Siegel, Florence Siepmann
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