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https://www.sciencedirect.com/topics/nursing-and-health-professions/transdermal-drug-delivery-system
Transdermal drug delivery systems facilitate the passage of therapeutic quantities of drug substances through the skin and into the general circulation for their systemic effects (Shaik et al., 2011). It has been found that drugs of herbal origin can be utilized with enhanced efficacy by incorporating them into transdermal drug patches.
https://newatlas.com/food-patch-delivers-nutrients-by-the-skin/1749/
Under development in the US for use by soldiers in the field, the Transdermal Nutrient Delivery System (TDNDS) is a nutrition patch that will transmit vitamins SUBSCRIBE AD-FREE LOG IN
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2700785/
Today, there are 19 transdermal delivery systems for such drugs as estradiol, fentanyl, lidocaine and testosterone; combination patches containing more than one drug for contraception and hormone replacement; and iontophoretic and ultrasonic delivery systems for analgesia (Table 1, Fig. 1). Between 1979 and 2002, a new patch was approved on average every 2.2 years.Author: Mark R Prausnitz, Robert Langer
https://www.pharmacytimes.com/publications/issue/2013/may2013/transdermal-drug-delivery-systems-the-skinny-on-cutaneous-reactions
Systems that intentionally allow drugs to enter systemic circulation have grown in popularity since the FDA approved the first TDS (scopolamine for motion sickness in 1979). 1-3 TDS benefits include drug delivery unaffected by food or gastrointestinal problems; avoidance of first-pass metabolism in the patient’s liver; diminished likelihood of hepatic induction; and a work-around delivery system for …
https://www.tandfonline.com/doi/abs/10.1080/13543776.2020.1742324
Transdermal drug delivery systems have been overcoming conventional administration because it can prevent drug degradation, and also improve the bioavailability and provide sustained drug release. Microneedles are a painless technology for drug delivery into skin and cannot cause any discomfort and cross-infection compared to traditional needle stick injuries, allowing patient compliance to the treatment.
https://www.fda.gov/media/98634/download
Assessing Adhesion With Transdermal and Topical Delivery Systems for ANDAs Guidance for Industry DRAFT GUIDANCE This guidance document is being distributed for comment purposes only.
https://www.fda.gov/industry/generic-drug-user-fee-amendments/fys-2013-2017-gdufa-science-and-research-report-transdermal-drug-products
This research included studies performed in vivo using TDS products and parenteral formulations that measured the plasma/serum concentrations of the drugs in human subjects. The two projects were: Heat Effect on Generic Transdermal Drug Delivery Systems (PI: …
https://www.tandfonline.com/doi/abs/10.1080/10543406.2019.1657440
Until 2016, a ratio of means (ROM) non-inferiority (NI) test was recommended in FDA product-specific guidances (PSGs) to evaluate adhesion performance for prospective generic transdermal delivery systems (TDS). However, the ROM NI test had low power for well-adhering TDS, which were becoming increasingly prevalent.Author: Wanjie Sun, Stella Grosser, Carol Kim, Sam G. Raney
https://www.researchgate.net/publication/270015915_Transdermal_drug_delivery_system_An_overview
Transdermal drug delivery system (TDDS) is one of the systems lying under the category of controlled drug delivery, in which the aim is to deliver the drug through the skin in a predetermined and ...
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