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https://www.sciencedirect.com/science/article/pii/S014296120900012X
However, simple drug delivery systems cannot fulfill the needs of such therapy. Therefore, developing the dual-drug delivery systems which can control the release behavior of each drug is desired. However, limited researches on the dual-drug delivery system (DDDS) are reported so far.Author: Lan Wei, Chunhua Cai, Jiaping Lin, Tao Chen
https://www.ncbi.nlm.nih.gov/pubmed/29960036
Sep 05, 2018 · The drug loaded rings were implanted separately within the periphery of the contact lenses using the modified cast moulding technology. The atomic force microscopy report showed an average roughness of 22.27 nm for the implant lens, which was significantly lower in comparison to the marketed Freshlook® (116.27 nm) contact lens.Author: Furqan A. Maulvi, Sulabh S. Singhania, Ankita R. Desai, Manish R. Shukla, Aniruddha S. Tannk, Ketan ...
https://pubs.acs.org/doi/10.1021/la3016436
Due to pH-responsive deoxycholic acid (pKa = 6.2) and thermo responsive N-isopropylacrylamide included in the ionic complex, the INPs exhibit highly pH and thermal dual-responsive properties. The potential practical applications as drug delivery carriers were demonstrated using doxorubicin (DOX) as a model drug.Author: Wei Cui, Xuemin Lu, Kun Cui, Lvye Niu, Yen Wei, Qinghua Lu
https://www.sciencedirect.com/science/article/abs/pii/S0168365919300343
Redox/pH dual-stimuli responsive camptothecin prodrug nanogels for “on-demand” drug delivery. Author links open overlay panel Ying Qu 1 Bingyang Chu 1 Xiawei Wei Minyi Lei Danrong Hu Ruoyu Zha Lin Zhong Mengyao Wang Fangfang Wang Zhiyong Qian. Show more.Author: Ying Qu, Bingyang Chu, Xiawei Wei, Minyi Lei, Danrong Hu, Ruoyu Zha, Lin Zhong, Mengyao Wang, Fangfa...
https://onlinelibrary.wiley.com/doi/full/10.1002/adma.201806957
Mar 11, 2019 · A dual bioresponsive drug delivery depot is engineered, which can respond to the acidic pH and reactive oxygen species within the tumor microenvironment (TME), for codelivery of …Author: Huitong Ruan, Quanyin Hu, Quanyin Hu, Di Wen, Di Wen, Qian Chen, Qian Chen, Guojun Chen, Guojun Chen...
https://onlinelibrary.wiley.com/doi/full/10.1002/adfm.201901896
Tumor Microenvironment‐Responsive Dual Drug Dimer‐Loaded PEGylated Bilirubin Nanoparticles for Improved Drug Delivery and Enhanced Immune‐Chemotherapy of Breast Cancer. Xiaotong Yang. Key Laboratory of Drug Targeting and Drug Delivery System of the Education Ministry, Sichuan Engineering Laboratory for Plant‐Sourced Drug and Sichuan ...Author: Xiaotong Yang, Chuan Hu, Fan Tong, Rui Liu, Yang Zhou, Lin Qin, Liang Ouyang, Huile Gao
https://www.hindawi.com/journals/jnm/2020/7147130/
A dual-targeting drug delivery system (DTDDS) with magnetic targeting and active targeting was obtained to improve the targeting and drug-loading capacity of magnetic drug nanocarriers. An ultraviolet-visible spectrophotometer and flow cytometry were used to investigate the drug-loading and release capacity, cytotoxicity, and inhibition of tumor cell proliferation, separately. Results show ...Author: Jinglei Du, Qiang Li, Lin Chen, Shicai Wang, Li Zhang, Shiping Yu, Shiping Yu, Yongzhen Yang, Xuguan...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2751731/
Targeted drug delivery using the folate-modified nanoparticles will be useful for treating cancer while minimizing the toxicity to the surrounding normal tissues. Combining the facile procedures and the targeting aspect with the dual-imaging capability, these nanoparticles may prove valuable for simultaneous imaging and drug delivery purposes.
https://pubs.acs.org/doi/10.1021/acs.chemmater.7b00047
Programmed drug delivery was achieved by a dual response of the extracellular acid and intracellular reductive environment. In vitro studies of the SDDS made it possible to visualize faster cellular uptake at pH 6.8 than at pH 7.4 because of the re-exposure of cationic charges and subsequent successful delivery of CPT to the cell nucleus.Author: Wenyu Cheng, Hong Cheng, Shuangshuang Wan, Xianzheng Zhang, Meizhen Yin
https://www.medscape.com/viewarticle/839286_4
Nov 06, 2019 · Dual-drug Delivery Systems . It has been shown that nanoparticle-based systems loaded with single CSC-targeting drugs are effective in reducing the …
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