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https://www.ncbi.nlm.nih.gov/pubmed/17873406
1. Mol Biotechnol. 2007 Jul;36(3):184-204. Gene delivery by lentivirus vectors. Cockrell AS(1), Kafri T. Author information: (1)Gene Therapy Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. The capacity to efficiently transduce nondividing cells, shuttle large genetic payloads, and maintain stable long-term transgene expression are attributes that have brought ...Author: Adam S. Cockrell, Tal Kafri
https://link.springer.com/article/10.1007/s12033-007-0010-8
Apr 17, 2007 · The capacity to efficiently transduce nondividing cells, shuttle large genetic payloads, and maintain stable long-term transgene expression are attributes that have brought lentiviral vectors to the forefront of gene delivery vehicles for research and therapeutic applications in a clinical setting. Our discussion initiates with advances in lentiviral vector development and how these ...Author: Adam S. Cockrell, Tal Kafri
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3507026/
Jul 06, 2012 · Viral and nonviral delivery systems for gene delivery. ... There are different viral and nonviral vectors for gene delivery, but all gene therapy applications depend on the fact that the genetic material needs to be delivered across the cell membrane and ultimately to the cell nucleus. ... Kafri T. Gene delivery by lentivirus vectors an ...
https://www.liebertpub.com/doi/10.1089/hum.2019.127
Dec 16, 2019 · There are many kidney diseases that might be addressed by gene therapy. However, gene delivery to kidney cells is inefficient. This is due, in part, to the fact that the kidney excludes molecules above 50 kDa and that most gene delivery vectors are megaDaltons in mass.Author: Jeffrey D. Rubin, Tien V. Nguyen, Kari L. Allen, Katayoun Ayasoufi, Michael A. Barry
https://www.researchgate.net/publication/5970268_Gene_delivery_by_lentivirus_vectors
Because the lentivirus vectors provide efficient gene delivery, cause minimal immune reactions in vivo, and can be integrated into the non-dividing cell genome to achieve stable long-term ...
https://www.researchgate.net/publication/226597815_Gene_Delivery_by_Lentivirus_Vectors
Background: Adenovirus, retrovirus and lentivirus-based vectors, originally engineered and optimized for in vivo and ex vivo gene therapy, have become increasingly useful for viral-mediated gene ...Author: Tal Kafri
https://seekingalpha.com/article/4305556-gene-therapy-series-2-delivery-systems-in-gene-therapy-including-viral-vectors
Nov 11, 2019 · In the ex vivo delivery, lentivirus vectors dominate the delivery approaches. In the overall landscape, currently, AAV based in vivo therapies dominate the gene therapy space outside oncology.
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