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https://www.researchgate.net/publication/269925223_Delivery_Strategies_for_Stem_Cell-Based_Therapy
8 Delivery Strategies for Stem Cell-Based Therapy For both of these approaches, in terms of clinical translation, expendable human tissues such as the intra-abdominal omentum might be ideal.
https://www.hindawi.com/journals/jhe/2012/203850/
Before stem cell-based therapies can become a clinical reality, technologies for cell delivery must be developed that can control differentiation and pluripotency, maintain a hospitable environment for cell survival and function, and provide a structural framework for regenerative healing of the target tissue. Insights gained from developmental and stem cell biology should guide the design of ...
https://www.sciencedirect.com/science/article/abs/pii/S0169409X16301338
Stem cell-based therapies form an exciting new class of medicine that attempt to provide the body with the building blocks required for the reconstruction of damaged organs. However, delivering cells to the correct location, while preserving their integrity and functional properties, is a complex undertaking.
https://www.sciencedirect.com/science/article/pii/S0168365919307254
In recent years, the mechanisms driving IUAs treatment has validated the application of hormones, and further stem cell therapy has also led to the development of novel therapeutic agents with promising efficacy in pre-clinical and initial clinical studies. Still, it is challenging to delivery the therpaeutic factors to the injured uterus.Author: Longfa Kou, Xue Jiang, Shuyi Xiao, Ying-Zheng Zhao, Qing Yao, Ruijie Chen
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299977/
Dec 19, 2018 · Moreover, stem cell-based cell therapy has been hampered by poor survival of transplanted stem cells in vivo. Therefore, there is a need to develop stem cell-activating factors that enhance the survival, paracrine effects, and therapeutic efficacy of transplanted stem cells.Author: Seong Gyu Kwon, Yang Woo Kwon, Tae Wook Lee, Gyu Tae Park, Jae Ho Kim
https://www.ncbi.nlm.nih.gov/pubmed/30121644
In order to optimize stem cell efficiency, it is crucial to elucidate the underlying mechanisms mediating the beneficial effects of stem cell transplantation. Based on these mechanisms, researchers have developed different improvement strategies to boost the potency of stem cell repair and to generate the "next generation" of stem cell ...Author: Paula Müller, Heiko Lemcke, Robert David
https://stemcellres.biomedcentral.com/articles/10.1186/s13287-019-1268-z
Jun 25, 2019 · To fully exploit the potential of these vectors, we must develop methods that improve intratumoral dissemination and allow for systemic delivery. This study establishes a proof-of-principle rationale for a novel human mesenchymal stem (stromal) cell-based approach to improving vector delivery to tumors.Author: Tahir Muhammad, Ali Sakhawat, Aamir Ali Khan, Ling Ma, Ruth A. Gjerset, Yinghui Huang
https://www.hindawi.com/journals/sci/2019/3620546/
2.3. Strategies for Cell Delivery. Cell delivery techniques should maximize regenerative benefits while minimizing side effects . In humans, both the portal vein and the hepatic artery are considered as safe administration routes in liver cell therapy.Author: Lorenzo Nevi, Samira Safarikia, Sabina Di Matteo, Francesca Biancaniello, Michele Francesco Chiappet...
https://www.nature.com/articles/s41401-019-0287-8
Aug 23, 2019 · In this review we focus on TRAIL gene therapy and various design strategies of TRAIL DNA delivery including non-viral vectors and cell-based …Author: Hui-hai Zhong, Hui-hai Zhong, Hui-yuan Wang, Jian Li, Yong-zhuo Huang
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