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https://www.researchgate.net/publication/7169194_Delivery_Strategies_for_siRNA-mediated_Gene_Silencing
Request PDF Delivery Strategies for siRNA-mediated Gene Silencing RNA interference (RNAi) represents a promising new gene silencing technology for functional genomics and a potential ...
http://www.eurekaselect.com/openurl/content.php?genre=article&issn=1567-2018&volume=3&issue=2&spage=147
Keywords:Short interfering RNA, design, delivery, RNA interference, RNAi, antisense oligonucleotides, transfection, gene therapy. Abstract: RNA interference (RNAi) represents a promising new gene silencing technology for functional genomics and a potential therapeutic strategy for a variety of genetic diseases. RNAi involves the targeted post ...
https://www.sciencedirect.com/science/article/pii/S0169409X16301521
In order to develop siRNAs as therapeutic agents for cancer treatment, delivery strategies for siRNA must be carefully designed and potential gene targets carefully selected for optimal anti-cancer effects. In this review, various modifications and delivery strategies for siRNA delivery are discussed.Author: So Jin Lee, So Jin Lee, Min Ju Kim, Min Ju Kim, Min Ju Kim, Ick Chan Kwon, Ick Chan Kwon, Thomas M. ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC506802/
The task of specific gene knockdown in vitro has been facilitated through the use of short interfering RNA (siRNA), which is now widely used for studying gene function, as well as for identifying and validating new drug targets. We explored the possibility of using siRNA for dissecting cellular pathways by siRNA-mediated gene silencing followed by gene expression profiling and systematic ...Author: Dimitri Semizarov, Paul Kroeger, Stephen Fesik
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2096447/
Dec 03, 2007 · Nonviral delivery of synthetic siRNAs in vivo. Saghir Akhtar 1, 2 and Ibrahim F. Benter 2 . ... Hollins A.J., Akhtar S. Delivery strategies for siRNA-mediated gene silencing. Current Drug Deliv. 2006; 3:147–155. 18. Akhtar S., Benter I. Toxicogenomics of non-viral drug delivery systems for RNAi: Potential impact on siRNA-mediated gene ...Author: Saghir Akhtar, Ibrahim F. Benter
https://www.sciencedirect.com/science/article/pii/S0169409X19300547
In particular, a lipopetide material termed cKK-E12, , was developed and show to be the most potent and selective siRNA delivery systems for gene silencing reported thus far for hepatocytes . Meanwhile, Whitehead and co-workers made a series of biodegradable lipidoids such as 503-O13 .Author: Yizhou Dong, Daniel J. Siegwart, Daniel G. Anderson
https://pubs.acs.org/doi/10.1021/jacs.8b10021
Collectively, our results demonstrate that actively targeted delivery via the peptide-coated nanosystem is indeed more effective for siRNA-mediated gene silencing of Hsp27 and leads to a more pronounced reduction in proliferation than the nontargeted delivery system.Author: Yiwen Dong, Tianzhu Yu, Ling Ding, Erik Laurini, Yuanyu Huang, Yuanyu Huang, Mengjie Zhang, Yuhua We...
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