Delivery Strategies For Sirna Mediated Gene Silencing

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Delivery Strategies for siRNA-mediated Gene Silencing ...

    https://www.researchgate.net/publication/7169194_Delivery_Strategies_for_siRNA-mediated_Gene_Silencing
    Request PDF Delivery Strategies for siRNA-mediated Gene Silencing RNA interference (RNAi) represents a promising new gene silencing technology for functional genomics and a potential ...

Delivery Strategies for siRNA-mediated Gene Silencing ...

    http://www.eurekaselect.com/openurl/content.php?genre=article&issn=1567-2018&volume=3&issue=2&spage=147
    Delivery Strategies for siRNA-mediated Gene Silencing Author(s): Ian R. Gilmore , Stephen P. Fox , Andrew J. Hollins , Saghir Akhtar . Centre for Genome-basedTherapeutics, The Welsh School of Pharmacy, Cardiff University, RedwoodBuilding, King Edward VII Avenue, Cardiff, CF10 3XF, UK.

Delivery strategies and potential targets for siRNA in ...

    https://www.sciencedirect.com/science/article/pii/S0169409X16301521
    Thus, RNAi-mediated gene silencing in non-human primates has clearly demonstrated the therapeutic potential of this new class of drug using SNALP technology. Although cationic lipid-based siRNA delivery has demonstrated potential in therapy in various disease models, several hurdles remain to enter commercialization of this class of drugs.Author: So Jin Lee, So Jin Lee, Min Ju Kim, Min Ju Kim, Min Ju Kim, Ick Chan Kwon, Ick Chan Kwon, Thomas M. ...

Strategies, design, and chemistry in siRNA delivery ...

    https://www.sciencedirect.com/science/article/pii/S0169409X19300547
    In particular, a lipopetide material termed cKK-E12, , was developed and show to be the most potent and selective siRNA delivery systems for gene silencing reported thus far for hepatocytes . Meanwhile, Whitehead and co-workers made a series of biodegradable lipidoids such as 503-O13 .Author: Yizhou Dong, Daniel J. Siegwart, Daniel G. Anderson

Chitosan/interfering RNA nanoparticle mediated gene ...

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4401390/
    Although the degree of gene silencing by RNAi can vary from gene to gene, tissue to tissue, and animal to animal, RNAi is widely used for functional analysis of genes in mosquitoes and other insects 8,9. Three interfering RNA delivery strategies have been used in mosquitoes: microinjection, soaking/topical application, and ingestion.Author: Xin Zhang, Keshava Mysore, Keshava Mysore, Ellen Flannery, Kristin Michel, David W. Severson, Kun Ya...

Nanoparticles for siRNA-Based Gene Silencing in Tumor Therapy

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6198667/
    In addition to liposomes/lipid nanoparticles, popular gene delivery vehicles and new strategies in polymer-based and inorganic nanoparticles that we have developed are mentioned, with a focus on siRNA-based cancer gene therapy. ... This hybrid system was successful in siRNA-mediated P-gp gene silencing and sensitized the drug-resistant MCF-7 ...Author: Anish Babu, Ranganayaki Muralidharan, Narsireddy Amreddy, Meghna Mehta, Anupama Munshi, Rajagopal Ra...

siRNA-mediated gene silencing in vitro and in vivo ...

    https://www.nature.com/articles/nbt739
    Sep 16, 2002 · RNA interference is now established as an important biological strategy for gene silencing, but its application to mammalian cells has been …Author: Haibin Xia, Qinwen Mao, Henry L. Paulson, Beverly L. Davidson

Reversal of siRNA-mediated gene silencing in vivo Nature ...

    https://www.nature.com/articles/nbt.4136
    May 14, 2018 · Gene silencing by siRNAs in vivo is reversed using sequence-specific high-affinity oligonucleotides. We report rapid, potent reversal of GalNAc …Author: Ivan Zlatev, Adam Castoreno, Christopher R Brown, June Qin, Scott Waldron, Mark K Schlegel, Rohan De...

siRNAs and shRNAs: Tools for Protein Knockdown by Gene ...

    https://www.labome.com/method/siRNAs-and-shRNAs-Tools-for-Protein-Knockdown-by-Gene-Silencing.html
    Additionally, delivery of the siRNA or shRNA may not be possible in certain cell types. Some cells do not tolerate transfection and they may not be susceptible for delivery by viral vectors. An important factor in choosing between siRNA- and shRNA-mediated gene silencing methods is the length of both the assay and the half-life of the target ...Author: Erin P O’Keefe

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