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https://www.sciencedirect.com/science/article/pii/S2214574518301482
RNAi is envisaged not as a standalone pest control tool but rather as part of a synergistic approach. Critical to the success and safety of insect-targetting RNAi is the appropriate choice of delivery method. At present the most exciting innovations are the use of nanoparticles, and the expression of trigger RNAs by a range of microbes.Author: Miranda Ma Whitten
https://www.ncbi.nlm.nih.gov/pubmed/29243000
Effective delivery systems are essential to enable the full therapeutic potential of RNAi. An ideal nanocarrier not only addresses the challenges of delivering naked siRNA/miRNA, including its chemically unstable features, extracellular and intracellular barriers, and innate immune stimulation, but also offers "smart" targeted delivery.Author: Xiuhui Chen, Xiuhui Chen, Lingegowda S. Mangala, Cristian Rodriguez-Aguayo, Xianchao Kong, Gabriel L...
https://www.sciencedirect.com/science/article/pii/S0169409X19300547
A few polymer-based siRNA delivery systems have shown therapeutic potential in clinical trials . Examples of major classes of polymer-based delivery systems are discussed below. 7. siRNA-polymer bioconjugates. Direct conjugation of siRNA to polymers offers an attractive avenue to improve stability, pharmacokinetics, cellular uptake, and delivery.Author: Yizhou Dong, Daniel J. Siegwart, Daniel G. Anderson
https://link.springer.com/article/10.1007%2Fs10555-017-9717-6
Dec 14, 2017 · Over the past decade, great efforts have been undertaken to develop RNAi delivery systems that overcome these obstacles. This review presents an update on current progress in the therapeutic application of RNAi with a focus on cancer therapy and strategies for optimizing delivery systems, such as lipid-based nanoparticles.Author: Xiuhui Chen, Xiuhui Chen, Lingegowda S. Mangala, Cristian Rodriguez-Aguayo, Xianchao Kong, Gabriel L...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2977003/
Jun 11, 2010 · Due to the similar physicochemical properties between DNA and siRNA, carriers developed for DNA have also been applied to siRNA. These carriers can be broadly divided into two categories, i.e., viral and non-viral. Readers are referred to a recent review on viral delivery systems for RNAi . In part due to the potential toxicities associated ...Author: Jie Wang, Ze Lu, M. Guillaume Wientjes, Jessie L.-S. Au
https://www.mdpi.com/2079-4991/10/1/146/htm
Therefore, further research is required in order to achieve the optimal calcium phosphate nanoparticles-based systems for RNAi delivery for bone tissue regeneration. Bone-related injury and disease constitute a significant global burden both socially and economically. Current treatments have many limitations and thus the development of new ...Author: Tanya J. Levingstone, Simona Herbaj, John Redmond, Helen O. McCarthy, Nicholas J. Dunne
https://www.liebertpub.com/doi/10.1089/nat.2018.0726
Jun 01, 2018 · There are certainly multiple contributing factors, but the repurposing of advanced nucleic acid delivery systems for mRNA applications is an important facilitator of this phenomenon. LNPs are most advanced delivery systems for siRNA so it comes as no surprise that most of the clinical activity in mRNA medicine use these systems.Author: Matthew G. Stanton
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