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https://www.researchgate.net/publication/324692258_RNAi_RNA_Interference_A_Therapeutic_Strategy_for_Aquaculture
systemic delivery strategies reported for higher animals, viz., ... RNAi is triggered by small interfering RNA (siRNA), which is processed by Dicer, an endoribonuclease, from exogenous or ...
https://www.intechopen.com/books/gene-therapy-developments-and-future-perspectives/gene-therapy-using-rnai
Thus, gene therapy using RNAi should be effective in ablating protein function since mRNA is the template for the translation of multiple proteins. Much of the interest in RNAi is based on the fact that the RNAi mechanism operates upstream of protein production by eliminating the mRNAs coding for such proteins. ... The RNAi delivery strategies ...
https://www.alnylam.com/web/Files/Events/ALNY-RNAiRoundtable-Delivery-090625.pdf
RNAi Delivery Strategies Direct RNAi Systemic RNAi Multiple major diseases » Metabolic » Viral disease Respiratory » RSV/Influenza » Cystic fibrosis » Asthma/COPD Viral disease » Cancer » Inflammation » Cardiovascular Ocular » AMD/Retinopathy » Glaucoma CNS » Neuropathic pain » Spinal cord injury » HuntingtonHuntingtons’s disease ...
http://www.eurekaselect.com/openurl/content.php?genre=article&issn=1567-2018&volume=3&issue=2&spage=147
Keywords:Short interfering RNA, design, delivery, RNA interference, RNAi, antisense oligonucleotides, transfection, gene therapy. Abstract: RNA interference (RNAi) represents a promising new gene silencing technology for functional genomics and a potential therapeutic strategy for a variety of genetic diseases. RNAi involves the targeted post ...
https://www.nature.com/articles/7700931
Jan 20, 2006 · Table 3 summarizes the currently available strategies for RNAi delivery in different systems. Table 3 RNAi delivery strategies. Full size table. RNAi and functional genomics.
https://www.cell.com/molecular-therapy-family/molecular-therapy/pdf/S1525-0016(17)30099-0.pdf
propelled the development of novel targeted delivery systems relying on the accumulating research knowledge from multi-ple disciplines, including materials science and engineering, immunology, and genetics. Here, we will discuss the recent progress in non-viral delivery strategies of RNAi …
https://www.slideshare.net/IshaqueAbdulla/si-rna
Nov 19, 2013 · si RNA (Small Interfering RNA) By, ISHAQUE P.K BIOCHEMISTRY pondicherry university Slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. If you continue browsing the site, you agree to the use of cookies on this website.
https://en.wikipedia.org/wiki/RNA_interference
RNA interference (RNAi) is a biological process in which RNA molecules inhibit gene expression or translation, by neutralizing targeted mRNA molecules. Historically, RNAi was known by other names, including co-suppression, post-transcriptional gene silencing (PTGS), and quelling. The detailed study of each of these seemingly different processes ...
https://www.nature.com/articles/nchembio839
Comparison of different delivery strategies for RNAi. Effective delivery is perhaps the most challenging remaining consideration for successful translation of RNAi to the clinic and to broad use ...
https://pubs.rsc.org/en/content/articlelanding/2015/mb/c5mb00278h
However, to bring about therapeutic success, an efficient delivery carrier that can cross the blood–brain barrier and reach the targeted site is essential. The current review focuses on the potential of targeted, non-viral and viral particles containing RNAi therapeutic molecules as delivery strategies …
https://jbioleng.biomedcentral.com/articles/10.1186/s13036-018-0130-7
Broad translational success of RNA interference (RNAi) technology depends on the development of effective delivery approaches. To that end, researchers have developed a variety of strategies, including chemical modification of RNA, viral and non-viral transfection approaches, and incorporation with delivery vehicles such as polymer- and lipid-based nanoparticles, engineered and native proteins ...
https://molecular-cancer.biomedcentral.com/articles/10.1186/s12943-017-0683-y
Jul 28, 2017 · RNA interference (RNAi), a newly developed method in which RNA molecules inhibit gene expression, has recently received considerable research attention. In the development of RNAi-based therapies, nanoparticles, which have distinctive size effects along with facile modification strategies and are capable of mediating effective RNAi with targeting potential, are attracting extensive interest ...
https://www.cell.com/molecular-therapy-family/molecular-therapy/fulltext/S1525-0016(17)30099-0
The development of nanoparticles for efficient systemic delivery of RNAi molecules to lymphocytes is a daunting task. Mizrahy et al. review the challenges and recent opportunities in non-viral delivery strategies of RNAi payloads to lymphocytes and elaborate on the most promising ones.
https://link.springer.com/content/pdf/10.1186%2F2052-8426-2-5.pdf
Systemic delivery of RNAi molecules is currently consid-ered as the ‘Holy Grail’ of the field. Whereas topical and local RNAi delivery strategies have to employ internaliza-tion strategies and endosomal release approaches, systemic RNAi delivery strategies need to really on methods to evade the immune system, frame-up within small blood ...
http://www.eurekaselect.com/144854/article
These papers defined hurdles in RNAi delivery and also strategies to overcome these hurdles. This review discussed the existing hurdles for systemic administration of siRNA as therapeutic agents and highlights the various strategies to overcome these hurdles, including lipid-based nanoparticles and polymeric nanoparticles, and we also briefly ...
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