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https://www.researchgate.net/publication/269925223_Delivery_Strategies_for_Stem_Cell-Based_Therapy
8 Delivery Strategies for Stem Cell-Based Therapy For both of these approaches, in terms of clinical translation, expendable human tissues such as the intra-abdominal omentum might be ideal.
https://www.hindawi.com/journals/jhe/2012/203850/
Several strategies have been developed for surgical delivery of stem cells, including synthetic and biologic matrices for cell seeding, complex biochemical delivery devices for maintenance and modulation of stem cell properties, and smart constructs with the ability to adapt to the dynamic in vivo environment after implantation.
https://www.researchgate.net/publication/269925223_Delivery_Strategies_for_Stem_Cell-Based_Therapy/fulltext/5641304008aeacfd8936473e/269925223_Delivery_Strategies_for_Stem_Cell-Based_Therapy.pdf
Before stem cell-based therapies can become a clinical reality, technologies for cell delivery must be developed that can control differentiation and pluripotency, maintain a hospitable environment
https://www.sciencedirect.com/science/article/abs/pii/S0169409X16301338
Stem cell-based therapies form an exciting new class of medicine that attempt to provide the body with the building blocks required for the reconstruction of damaged organs. However, delivering cells to the correct location, while preserving their integrity and functional properties, is a complex undertaking.
https://www.sciencedirect.com/science/article/pii/S0169409X16301338
Stem cell-based therapy: Improving myocardial cell delivery ☆ 1. Stem cells as a therapeutic agent. At present day, stem cell therapy is a thriving area... 2. Cardiac cell therapy. As the blood supply to myocardium wanes,... 3. Pharmacokinetics of cell delivery to the heart. 4. Strategies to ...Author: Dries A.M. Feyen, Roberto Gaetani, Roberto Gaetani, Pieter A. Doevendans, Joost P.G. Sluijter
https://www.hindawi.com/journals/sci/2018/8490489/
Mechanical, biological, and chemical scaffolds can mitigate the disadvantages associated with cell-based therapy, such as insufficient integration into host tissues, inaccurate cell delivery, and degeneration of healthy cartilage. A scaffold-based approach has been developed to better fill cartilage lesions with autologous chondrocytes.Author: Yoojun Nam, Yeri Alice Rim, Jennifer Lee, Ji Hyeon Ju
https://www.sciencedirect.com/science/article/pii/S0168365918307223
Cell-based targeted delivery system (TDDS) has developed as a promising delivery strategy for its low immunogenicity, intrinsic mutation rate , long circulation time, no neurotoxicity or tumorigenicity, innate targeting capability, and integration of receptors .Author: Hong-Hui Wu, Yi Zhou, Yasuhiko Tabata, Jian-Qing Gao
https://stemcellsjournals.onlinelibrary.wiley.com/doi/full/10.1002/sctm.18-0024
The development of mesenchymal stem cells (MSCs) as cell‐based drug delivery vectors for numerous clinical indications, including cancer, has significant promise. However, a considerable challenge for effective translation of these approaches is the limited tumor tropism and broad biodistribution observed using conventional MSCs, which raises concerns for toxicity to nontarget …
https://www.sciencedirect.com/science/article/pii/S1471489217301376
Regenerative therapeutic strategies for cartilage defects and osteoarthritis. Exogenous cell-based therapy entails delivery of autologous or allogeneic cells such as chondrocytes or mesenchymal stromal/stem cells (MSCs), or extracellular vesicles (EVs), either in …Author: Cosimo De Bari, Anke J Roelofs
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4106911/
Jul 19, 2014 · Stem cells such as neural stem cells (NSCs) and mesenchymal stem cells (MSCs) can be used to delivery drugs or RNA to the brain. This use of methods to bypass the hurdles of delivering drugs across the BBB is particularly important for diseases with …
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