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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2977003/
Jun 11, 2010 · Lipid-based siRNA delivery systems include liposomes, micelles, microemulsions, and solid lipid nanoparticles . Liposomes are globular vesicles with an aqueous core and phospholipid bilayer, comprise natural body constituents (e.g., lipids, sterols), and are biocompatible and biodegradable.Author: Jie Wang, Ze Lu, M. Guillaume Wientjes, Jessie L.-S. Au
https://www.nature.com/articles/nmat3765
Oct 23, 2013 · RNA interference (RNAi) has broad potential as a therapeutic to reversibly silence any gene. To achieve the clinical potential of RNAi, delivery materials are required to transport short...Author: Rosemary Kanasty, Joseph Robert Dorkin, Arturo Vegas, Arturo Vegas, Daniel Anderson
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3255578/
Delivery of siRNA with Staramine/siCav-1 nanocomplexes modified with monodisperse mPEG515 resulted in a consistently slow clearance rate for the siRNA from the lung, compared to those composed of Star:Star-mPEG550, which showed more variable rates of clearance over multiple experiments.Author: Kevin J Polach, Majed Matar, Jennifer Rice, Gregory Slobodkin, Jeff Sparks, Richard Congo, Angela Re...
https://www.sciencedirect.com/science/article/pii/S1818087614000646
Most siRNA delivery systems undergo cellular internalization through endocytosis. Various delivery systems aim to improve the rate of cellular uptake by incorporating targeting ligands that bind specifically to receptors on target cells to induce receptor-mediated endocytosis .Author: Cong-fei Xu, Jun Wang
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6631009/
Jun 13, 2019 · Studies on siRNA delivery have seen intense growth in the past decades since siRNA has emerged as a new class of gene therapeutics for the treatment of various diseases. siRNA bioconjugate, as one of the major delivery strategies, offers the potential to enhance and broaden pharmacological properties of siRNA, while minimizing the heterogeneity and stability-correlated …Author: Wanyi Tai
https://www.nature.com/articles/nbt.1807
Mar 20, 2011 · The therapeutic potential of exosome-mediated siRNA delivery was demonstrated by the strong mRNA (60%) and protein (62%) knockdown of BACE1, a therapeutic target in …Author: Lydia Alvarez-Erviti, Yiqi Seow, HaiFang Yin, Corinne Betts, Samira Lakhal, Matthew J A Wood
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