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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2698461/
In fact, in the single clinical trial reported for RNAi delivery to brain tumor (which targeted tenancin-C), the siRNA was injected directly into infiltrative (inoperable) regions of brain tumor . Steady progress in tissue-targeting methods has enabled researchers to deliver siRNA to diseased tissues or organs via the systemic route with positive outcomes, including the brain.Author: Saroj P Mathupala
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3572210/
Mar 30, 2007 · The delivery of siRNA to brain is analogous to the delivery of antisense agents such as PNAs to brain. The studies reviewed in Figs. 6 and and7 7 demonstrate the delivery of PNA antisense agents to brain in vivo [ 43 ]. siRNA duplexes can be monobiotinylated [ 52 ], which allows for high efficiency attachment to molecular Trojan horses using avidin-biotin technology.Author: William M. Pardridge
https://www.nature.com/articles/nbt.1807
Mar 20, 2011 · The therapeutic potential of exosome-mediated siRNA delivery was demonstrated by the strong mRNA (60%) and protein (62%) knockdown of BACE1, a therapeutic target in Alzheimer's disease, in wild ...Author: Lydia Alvarez-Erviti, Yiqi Seow, HaiFang Yin, Corinne Betts, Samira Lakhal, Matthew J A Wood
https://www.nature.com/articles/nrn2205
Aug 01, 2007 · siRNA: brain delivery breakthrough. For the in vivo examination of siRNA delivery, mice were intravenously injected with a fluorescent siRNA–RVG–9R peptide complex. The uptake of the siRNA …Author: Alexandra Flemming
https://www.sciencedirect.com/science/article/pii/S0142961213009848
In this study, we describe intranasal brain delivery of siRNA or dextran (Mw: 10,000 Da) as a model siRNA, by using MPEG–PCL–Tat. Intranasal delivery of dextran with MPEG–PCL–Tat improved brain delivery compared to intravenous delivery of dextran either with or without MPEG–PCL–Tat.Author: T. Kanazawa, F. Akiyama, S. Kakizaki, Y. Takashima, Y. Seta
https://www.ncbi.nlm.nih.gov/pubmed/29422412
However, effective and safe systemic delivery of siRNA into the brain remains challenging because of biological barriers such as enzymatic degradation, short circulation lifetime, the blood-brain barrier (BBB), insufficient tissue penetration, cell endocytosis, and cytosolic transport.Author: Meng Zheng, Wei Tao, Yan Zou, Omid C. Farokhzad, Bingyang Shi
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