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https://www.nature.com/articles/nbt.1807
Mar 20, 2011 · The therapeutic potential of exosome-mediated siRNA delivery was demonstrated by the strong mRNA (60%) and protein (62%) knockdown …Author: Lydia Alvarez-Erviti, Yiqi Seow, HaiFang Yin, Corinne Betts, Samira Lakhal, Matthew J A Wood
https://www.ncbi.nlm.nih.gov/pubmed/21423189
The therapeutic potential of exosome-mediated siRNA delivery was demonstrated by the strong mRNA (60%) and protein (62%) knockdown of BACE1, a therapeutic target in …Author: Lydia Alvarez-Erviti, Yiqi Seow, HaiFang Yin, Corinne Betts, Samira Lakhal, Matthew J A Wood
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3255578/
Delivery of siRNA exclusively to the endothelial cells of the lung may indicate direct transfer of the nanocomplexes from circulation to the cells lining the capillary bed.Author: Kevin J Polach, Majed Matar, Jennifer Rice, Gregory Slobodkin, Jeff Sparks, Richard Congo, Angela Re...
https://altogen.com/InVivoTransfection3.pdf
siRNA delivery was demonstrated by the strong mRNA (60%) and protein (62%) knockdown of BACE1, a therapeutic target in Alzheimer’s disease, in wild-type mice. Despite recent advances in delivering siRNA, targeting specific tissues or cell types while avoiding nonspecific delivery, especially to the liver, remains challenging.
https://www.europepmc.org/articles/PMC3255578/
Oct 11, 2011 · Intravenous (i.v.) administration of Staramine/siRNA nanocomplexes modified with methoxypolyethylene glycol (mPEG) provides safe and effective delivery of siRNA and significant target gene knockdown in the lungs of normal mice, with much lower knockdown in liver, spleen, and kidney.Author: Kevin J Polach, Majed Matar, Jennifer Rice, Gregory Slobodkin, Jeff Sparks, Richard Congo, Angela Re...
https://www.mirusbio.com/tech-resources/tips/deliver-sirna-in-vivo
siRNA is effectively delivered to the mouse liver using hydrodynamic tail vein injection and TransIT®-QR Delivery Solution. Given the similar size and structure of siRNAs and duplex miRNAs, this method should also deliver duplex miRNAs to the mouse liver with similar efficiency.
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