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https://www.nature.com/articles/nbt.1807
Mar 20, 2011 · Intravenously injected RVG-targeted exosomes delivered GAPDH siRNA specifically to neurons, microglia, oligodendrocytes in the brain, resulting in a specific gene knockdown. Pre-exposure to RVG...Author: Lydia Alvarez-Erviti, Yiqi Seow, HaiFang Yin, Corinne Betts, Samira Lakhal, Matthew J A Wood
https://www.ncbi.nlm.nih.gov/pubmed/21423189
Intravenously injected RVG-targeted exosomes delivered GAPDH siRNA specifically to neurons, microglia, oligodendrocytes in the brain, resulting in a specific gene knockdown. Pre-exposure to RVG exosomes did not attenuate knockdown, and non-specific uptake in other tissues was not observed.Author: Lydia Alvarez-Erviti, Yiqi Seow, HaiFang Yin, Corinne Betts, Samira Lakhal, Matthew J A Wood
https://altogen.com/InVivoTransfection3.pdf
siRNA delivery was demonstrated by the strong mRNA (60%) and protein (62%) knockdown of BACE1, a therapeutic target in Alzheimer’s disease, in wild-type mice. Despite recent advances in delivering siRNA, targeting specific tissues or cell types while avoiding nonspecific delivery, especially to the liver, remains challenging.
https://www.paediatrics.ox.ac.uk/publications/127173
Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes. To realize the therapeutic potential of RNA drugs, efficient, tissue-specific and nonimmunogenic delivery technologies must be developed.Author: Lydia Alvarez-Erviti, Yiqi Seow, HaiFang Yin, Corinne Betts, Samira Lakhal, Matthew J A Wood
https://www.academia.edu/15139145/Delivery_of_siRNA_to_the_mouse_brain_by_systemic_injection_of_targeted_exosomes
Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes
https://www.sigmaaldrich.com/catalog/papers/21423189
Intravenously injected RVG-targeted exosomes delivered GAPDH siRNA specifically to neurons, microglia, oligodendrocytes in the brain, resulting in a specific gene knockdown. Pre-exposure to RVG exosomes did not attenuate knockdown, and non-specific uptake in other tissues was not observed.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3572210/
Mar 30, 2007 · The delivery of siRNA to brain is analogous to the delivery of antisense agents such as PNAs to brain. The studies reviewed in Figs. 6 and and7 7 demonstrate the delivery of PNA antisense agents to brain in vivo [ 43 ]. siRNA duplexes can be monobiotinylated [ 52 ], which allows for high efficiency attachment to molecular Trojan horses using avidin-biotin technology.Author: William M. Pardridge
https://www.nature.com/articles/nprot.2012.131
Nov 15, 2012 · By using this method, we demonstrated specific delivery of siRNA to neurons in the brain following systemic delivery in mice, with up to 60% RNA and protein knockdown predominantly in the midbrain, cortex and striatum, and little homing of exosome cargo to the liver.Author: Samir El-Andaloussi, Samir El-Andaloussi, Yi Lee, Samira Lakhal-Littleton, Jinghuan Li, Yiqi Seow, C...
https://exrna.biomedcentral.com/articles/10.1186/s41544-019-0034-9
Dec 03, 2019 · Intravenous injection such modified exosomes into normal mice led to efficient delivery of siRNA to the brain and consequently knockdown of BACE1 gene, highlighting the therapeutic value of this new RNAi strategy . In this study, we developed a novel strategy for lung cancer treatment by employing exosome-mediated siRNA delivery.Author: Yu Zhou, Yuan Yuan, Minghui Liu, Xiuting Hu, Yiming Quan, Xi Chen
https://www.sciencedirect.com/science/article/pii/S0142961213009848
In this study, we describe intranasal brain delivery of siRNA or dextran (Mw: 10,000 Da) as a model siRNA, by using MPEG–PCL–Tat. Intranasal delivery of dextran with MPEG–PCL–Tat improved brain delivery compared to intravenous delivery of dextran either with or without MPEG–PCL–Tat.Author: T. Kanazawa, F. Akiyama, S. Kakizaki, Y. Takashima, Y. Seta
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