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http://kinampark.com/PLGARef/files/Pisal%202010%2C%20Delivery%20of%20therapeutic%20proteins.pdf
targeted drug delivery, may be efficiently used to decrease the clearance, alter the distribution, or even enhance the delivery of therapeutic molecules. Increases in protein stability have been reported as a result of PEG masking hydrophobic sites on the proteins’ surface involved in noncovalent interactions
https://onlinelibrary.wiley.com/doi/abs/10.1002/jps.22054
Delivery of therapeutic proteins Dipak S. Pisal Department of Pharmaceutical Sciences, 521 Hochstetter Hall, University at Buffalo, The State University of New York, Amherst, New York 14260Author: Dipak S. Pisal, Matthew P. Kosloski, Sathy V. Balu-Iyer
https://www.sciencedirect.com/science/article/abs/pii/S0022354915326241
The safety and efficacy of protein therapeutics are limited by three interrelated pharmaceutical issues, in vitro and in vivo instability, immunogenicity and shorter half-lives.Author: Dipak S. Pisal, Matthew P. Kosloski, Sathy V. Balu-Iyer
https://www.researchgate.net/publication/40848801_Delivery_of_Therapeutic_Proteins
Although conceptually obvious, the effective delivery of proteins in therapeutic applications is far from being a routine practice. The major limitation is the conservation of protein...
https://www.sciencedirect.com/science/article/pii/S0022354915326241
The PLGA microspheres for protein delivery can be prepared by several methods with the most widely used techniques for proteins conjugation being: (i) spray drying, (ii) double emulsion, and (iii) phase separation-coacervation. 92Author: Dipak S. Pisal, Matthew P. Kosloski, Sathy V. Balu-Iyer
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2857543/
Lipid drug delivery is another area that has shown great promise for use with therapeutic proteins. 116 – 118 As a whole, lipid delivery encompasses liposomes, solid lipid nanoparticles, oily suspensions, submicron lipid emulsions, lipid implants, lipid microbubbles, inverse lipid micelles, cochliar liposomes, and lipid microtubules, and lipid microcylinders (Figure 3A). 119 The most …Author: Dipak S. Pisal, Matthew P. Kosloski, Sathy V. Balu-Iyer
https://pubs.rsc.org/en/content/articlelanding/2017/tb/c7tb00244k
Nowadays, protein therapeutics receive unprecedented recognition for their great potential in the treatment of a variety of diseases. The efficacy of native therapeutic proteins is limited by their intrinsic poor stability and cell membrane permeability. Tremendous efforts have been devoted to developing efficient protein delivery systems.Author: Meihua Yu, Zhengying Gu, Thomas Ottewell, Thomas Ottewell, Chengzhong Yu
http://www.eurekaselect.com/137691/article
In order to keep these therapeutic proteins safe from enzymatic degradation and improve their therapeutic efficacy, several strategies have been designed and investigated various therapeutic delivery routes for efficient delivery of therapeutic proteins …
https://www.nature.com/articles/nbt.1733
Jan 09, 2011 · Current viral vectors for gene therapy are associated with serious safety concerns, including leukemogenesis, and nonviral vectors are limited by low gene transfer efficiency. Here we investigate the therapeutic utility of chemically modified mRNA as an alternative to DNA-based gene therapy.Author: Michael S D Kormann, Günther Hasenpusch, Manish K Aneja, Gabriela Nica, Andreas W Flemmer, Susanne H...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2835060/
Jan 30, 2009 · Physical delivery of TAT fusion proteins such as direct injection into the tumor bed is inefficient as the recombinant protein may not reach all the cells within the tumor mass. In addition, therapeutic delivery of proteins in vivo can result in the degradation by proteases and rapid elimination by renal filtration. 11 Therefore multiple applications of the fusion proteins would be necessary.Author: Marcella Flinterman, Farzin Farzaneh, Nagy Habib, Farooq Malik, Joop Gäken, Mahvash Tavassoli
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