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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2857543/
Lipid drug delivery is another area that has shown great promise for use with therapeutic proteins. 116 – 118 As a whole, lipid delivery encompasses liposomes, solid lipid nanoparticles, oily suspensions, submicron lipid emulsions, lipid implants, lipid microbubbles, inverse lipid micelles, cochliar liposomes, and lipid microtubules, and lipid microcylinders (Figure 3A). 119 The most …Author: Dipak S. Pisal, Matthew P. Kosloski, Sathy V. Balu-Iyer
https://www.sciencedirect.com/science/article/pii/S0022354915326241
Some of these technologies have successfully made to market, but delivery of required therapeutic concentration of protein or peptide product to its site of action, specifically when the target is outside of the systemic circulation, without any substantial adverse reactions is still a challenge to overcome.Author: Dipak S. Pisal, Matthew P. Kosloski, Sathy V. Balu-Iyer
https://www.sciencedirect.com/science/article/abs/pii/S0022354915326241
The safety and efficacy of protein therapeutics are limited by three interrelated pharmaceutical issues, in vitro and in vivo instability, immunogenic…Author: Dipak S. Pisal, Matthew P. Kosloski, Sathy V. Balu-Iyer
http://www.eurekaselect.com/137691/article
Recent advances in genetic engineering and pharmaceutical biotechnology have made possible to combat life-threatening diseases with efficient delivery of therapeutic proteins. These advancements have increased the significance of therapeutic proteins in pharmaceutical market, but their therapeutic delivery to the targeted site is still a major obstacle to achieve desired therapeutic outcomes.
https://www.researchgate.net/publication/40848801_Delivery_of_Therapeutic_Proteins
Although conceptually obvious, the effective delivery of proteins in therapeutic applications is far from being a routine practice. The major limitation is the conservation of protein...
http://kinampark.com/PLGARef/files/Pisal%202010%2C%20Delivery%20of%20therapeutic%20proteins.pdf
targeted drug delivery, may be efficiently used to decrease the clearance, alter the distribution, or even enhance the delivery of therapeutic molecules. Increases in protein stability have been reported as a result of PEG masking hydrophobic sites on the proteins’ surface involved in noncovalent interactions
https://www.amazon.com/Inhalation-Delivery-Therapeutic-Peptides-Proteins/dp/0824797809
Summarizes over 130 patents granted worldwide on alternative systems for pulmonary delivery of therapeutic drugs-especially peptides and proteins! Examining macromolecular drug delivery as an efficient, patient-friendly, and cost-effective method of treatment, Inhalation Delivery of Therapeutic Peptides and Proteins discussesAuthor: Akwete Adjei
https://www.nature.com/articles/nbt.1733
Jan 09, 2011 · Current viral vectors for gene therapy are associated with serious safety concerns, including leukemogenesis, and nonviral vectors are limited by low gene transfer efficiency. Here we investigate the therapeutic utility of chemically modified mRNA …Author: Michael S D Kormann, Günther Hasenpusch, Manish K Aneja, Gabriela Nica, Andreas W Flemmer, Susanne H...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2835060/
Jan 30, 2009 · Physical delivery of TAT fusion proteins such as direct injection into the tumor bed is inefficient as the recombinant protein may not reach all the cells within the tumor mass. In addition, therapeutic delivery of proteins in vivo can result in the degradation by proteases and rapid elimination by renal filtration. 11 Therefore multiple applications of the fusion proteins would be necessary.Author: Marcella Flinterman, Farzin Farzaneh, Nagy Habib, Farooq Malik, Joop Gäken, Mahvash Tavassoli
https://www.wisegeek.com/what-is-therapeutic-protein.htm
Oct 03, 2019 · A major group of useful substances in biology are proteins, and the body makes many of these naturally. Scientists discovered that, for some diseases, the delivery of a protein with a biological effect into the body could have beneficial effects on the patient. This type of protein medication is called therapeutic protein.
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