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https://www.ncbi.nlm.nih.gov/pubmed/11907197
Intranasal delivery of morphine. Illum L(1), Watts P, Fisher AN, Hinchcliffe M, Norbury H, Jabbal-Gill I, Nankervis R, Davis SS. Author information: (1)West Pharmaceutical Services, Drug Delivery and Clinical Research Centre Ltd., Albert Einstein Centre, Nottingham Science and Technology Park, Nottingham, United Kingdom. lisbeth_illum@ ...Author: L. Illum, P. Watts, A. N. Fisher, M. Hinchcliffe, H. Norbury, I. Jabbal-Gill, R. Nankervis, S. S. Da...
http://jpet.aspetjournals.org/content/301/1/391
Apr 01, 2002 · Morphine administered nasally to humans as a simple solution is only absorbed to a limited degree, with a bioavailability of the order of 10% compared with intravenous administration. This article describes the development of novel nasal morphine formulations based on chitosan, which, in the sheep model, provide a highly increased absorption with a 5- to 6-fold increase in bioavailability over ...Author: L. Illum, P. Watts, A. N. Fisher, M. Hinchcliffe, H. Norbury, I. Jabbal-Gill, R. Nankervis, S. S. Da...
https://www.researchgate.net/publication/277450427_Intranasal_Delivery_of_Morphine
Intranasal Delivery of Morphine. ... Intranasal delivery is one of the most interesting and challenging endeavors facing pharmaceutical scientists. The conventional nasal drug delivery systems ...
https://www.researchgate.net/publication/11457494_Intranasal_delivery_of_morphine
Intranasal Delivery of Morphine 399 Aspden TJ, Mason JDT, Jones NS, Lowe J, Skaugrud O, and Illum L (1997a) Chitosan as a nasal delivery system: the effect of chitosan solutions on the in vitro
http://cosmas-damian.co.uk/1/morphine391%5b1%5d.pdf
Intranasal Delivery of Morphine L. ILLUM, P. WATTS, A. N. FISHER, M. HINCHCLIFFE, H. NORBURY, I. JABBAL-GILL, R. NANKERVIS, and S. S. DAVIS West Pharmaceutical ...
http://intranasal.net/PainControl/INpaincontroldefault.htm
Intranasal opiates are simply one of many treatment options that may be useful in selected patients. For selected opiate medications, intranasal delivery can result in rapid medication absorption with serum and cerebral spinal fluid (CSF) levels approaching those comparable to intravenous (IV) administration.
https://www.sciencedirect.com/science/article/pii/S1754320710000039
1. Introduction. In the treatment of cancer pain, the World Health Organisation (WHO) and the European Association for Palliative Care (EAPC) have recommended oral administration as the optimal route for drug delivery (World Health Organization, 1996, Hanks et al., 2001).However, typical oral analgesics (e.g., immediate-release opioids, such as morphine) have relatively slow onsets of action ...Author: Ola Dale
https://www.hindawi.com/journals/prm/2018/7276021/
Objective . To investigate the pharmacokinetics (PK) of Morphine ARER, an extended-release (ER), abuse-deterrent formulation of morphine sulfate after oral and intranasal administration. Methods . This randomized, double-blind, double-dummy, placebo-controlled, four-way crossover study assessed the PK of morphine and its active metabolite, M6G, from crushed intranasal Morphine ARER and intact ...Author: Lynn R. Webster, Carmela Pantaleon, Matthew Iverson, Michael D. Smith, Eric R. Kinzler, Stefan Aigne...
http://intranasal.net/Overview/default.htm
Intranasal medication delivery - brief overview of the concept. Disclaimer: The information on this web site is for educational and informational purposes only. It is not professional medical advice nor is it intended to substitute for such.
http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.598.3550
CiteSeerX - Document Details (Isaac Councill, Lee Giles, Pradeep Teregowda): Morphine administered nasally to humans as a simple solution is only absorbed to a limited degree, with a bioavailability of the order of 10 % compared with intravenous administration. This article describes the development of novel nasal morphine formulations based on chitosan, which, in the sheep model, provide a ...
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