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https://www.sciencedirect.com/science/article/pii/S0168365914004465
Cytochrome c end-capped mesoporous silica nanoparticles as redox-responsive drug delivery vehicles for liver tumor-targeted triplex therapy in vitro and in vivo. Author links open overlay panel Beilu Zhang Zhong Luo Junjie Liu Xingwei Ding Jinghua Li Kaiyong Cai 1. Show more.Author: Beilu Zhang, Zhong Luo, Junjie Liu, Xingwei Ding, Jinghua Li, Kaiyong Cai
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0195542
One of the major drawbacks of many of the currently used cancer drugs are off-target effects. Targeted delivery is one method to minimize such unwanted and detrimental events. To actively target lung cancer cells, we have developed a conjugate of the apoptosis inducing protein cytochrome c with transferrin because the transferrin receptor is overexpressed by many rapidly dividing cancer cells ...Author: Manoj Saxena, Yamixa Delgado, Rohit Kumar Sharma, Shweta Sharma, Solimar Liz Ponce De León Guzmán, A...
http://medcraveonline.com/JNMR/JNMR-01-00010.pdf
Enhancement of the Cytotoxic Effect of Anticancer Agent by Cytochrome c Functionalised Hybrid Nanoparticles in Hepatocellular Cancer Cells Research Article Volume 1 Issue 2 - 2014 Maryam Malekigorji, Clare Hoskins, Tony Curtis and Gabor Varbiro* School of Pharmacy, Institute of Science and Technology in Medicine, Keele University, UK
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4237869/
However, it has been demonstrated that the targeted delivery of Cytochrome c directly to the cytoplasm of cancer cells selective initiates apoptosis in many cancer cells. In this work we designed a novel nano-sized smart Cytochrome c drug delivery system to induce apoptosis in cancer cells upon delivery.Author: Moraima Morales-Cruz, Cindy M Figueroa, Tania González-Robles, Yamixa Delgado, Anna Molina, Jessica ...
https://pubs.acs.org/doi/10.1021/mp400400j
Cytochrome c (Cyt c) is a small mitochondrial heme protein involved in the intrinsic apoptotic pathway. Once Cyt c is released into the cytosol, the caspase mediated apoptosis cascade is activated resulting in programmed cell death. Herein, we explore the covalent immobilization of Cyt c into mesoporous silica nanoparticles (MSN) to generate a smart delivery system for intracellular drug ...Author: Méndez J, Morales Cruz M, Delgado Y, Figueroa Cm, Orellano Ea, Morales M, Monteagudo A, Griebenow K
https://www.ncbi.nlm.nih.gov/pubmed/22365810
The targeted intracellular delivery of cytochrome C protein to tumors using lipid-apolipoprotein nanoparticles. Kim SK(1), Foote MB, Huang L. Author information: (1)Division of Molecular Pharmaceutics, Eshelman School of Pharmacy, University of …Author: Sang Kyoon Kim, Michael B. Foote, Leaf Huang
https://www.nature.com/articles/s41598-019-48037-z
Aug 13, 2019 · In this work, we have exploited the unique properties of a chimeric archaeal-human ferritin to encapsulate, deliver and release cytochrome c and induce apoptosis in a myeloid leukemia cell line.Author: Alberto Macone, Silvia Masciarelli, Federica Palombarini, Deborah Quaglio, Alberto Boffi, Matilde Ca...
http://www.eurekaselect.com/openurl/content.php?genre=article&issn=0929-8673&volume=15&issue=23&spage=2346
Keywords:Antibody-directed enzyme prodrug therapy (ADEPT), cyclic phosphate, cytochrome P450 enzyme, gene-directed enzyme prodrug therapy (GDEPT), N-oxide, nucleoside, oxazaphosphorine, oxime, prodrug, targeted drug delivery. Abstract: Cytochrome P450 (CYP) enzymes are a superfamily of heme containing proteins that catalyze xenobiotic ...
https://www.sciencedirect.com/science/article/pii/S0021979719312871
Delivery of apoptosis-associated proteins is an attractive approach to treat cancer, but their large molecular sizes and membrane-impermeability require the use of a suitable delivery carrier. As a versatile drug carrier, mesoporous silica nanoparticles (MSNs) have been utilized to transport a variety of therapeutic molecules.Author: Eunshil Choi, Eunshil Choi, Dong-Kwon Lim, Sehoon Kim, Sehoon Kim, Sehoon Kim
https://www.sigmaaldrich.com/life-science/metabolomics/enzyme-explorer/learning-center/cytochrome-c.html
Cytochrome c is a highly conserved ~12 kDa protein consisting of a single 104 amino acid peptide with a single heme group, which is covalently attached to Cys and Cys. Because of its ubiquitous nature and sequence homology, cytochrome c has been used as a model protein for molecular evolution.
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