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https://www.sciencedirect.com/science/article/pii/S0142961219304570
Cytosolic protein delivery offers opportunities to develop protein-based therapeutics specifically modulate intracellular processes, especially those linked to ‘undruggable’ targets. Since protein molecules are generally membrane-impermeable due to their macromolecular nature and hydrophilic property, carriers are needed to facilitate protein transport through cell membranes.Author: Jia Lv, Qianqian Fan, Hui Wang, Yiyun Cheng, Yiyun Cheng
https://www.nature.com/articles/nchem.2779
May 22, 2017 · We also demonstrate the L17E-mediated cytosolic delivery of exosome-encapsulated proteins. The trapping of antibodies in endosomes often limits their use …Author: Misao Akishiba, Toshihide Takeuchi, Yoshimasa Kawaguchi, Kentarou Sakamoto, Hao-Hsin Yu, Ikuhiko Nak...
https://pubs.acs.org/doi/10.1021/acsami.9b21131
Hydrodynamic approaches offer rapid and controllable delivery of small molecules, but thus far have not been demonstrated for delivering functional proteins. In this work, we developed a robust hydrodynamic approach based on gigahertz (GHz) acoustics to achieve rapid and non-invasive cytosolic delivery of biologically active proteins.Author: Shuting Pan, Shuting Pan, Taewon Jeon, David C. Luther, Xuexin Duan, Vincent M. Rotello
https://www.biorxiv.org/content/10.1101/236729v1
Dec 19, 2017 · A generic methodology for cytosolic delivery of large supramolecular multiprotein complexes into living cells is described that takes advantage of the highly-controllable bottom-up fabrication of protein-decorated DNA nanostructures and the microfluidic “cell squeezing” technique.Author: Pavel M. Nikolov, Katja J. Kossmann, Alessa Schilling, Alessandro Angelin, Josipa Brglez, Alina Klei...
https://pubs.rsc.org/en/content/articlelanding/2019/cc/c9cc00010k
Though plenty of viral and non-viral methods have been rapidly developed for the delivery of the CRISPR/Cas9 system, the direct delivery of Cas9 ribonucleoproteins (RNPs) into the nucleus for genome editing via the non-homologous end joining (NHEJ) or …Author: Jie Qiao, Wenli Sun, Siyu Lin, Rong Jin, Lixin Ma, Yi Liu
https://onlinelibrary.wiley.com/doi/abs/10.1002/anie.201806941
Jun 25, 2018 · Enhanced Cytosolic Delivery and Release of CRISPR/Cas9 by Black Phosphorus Nanosheets for Genome Editing. Dr. Wenhua Zhou. Center for Biomedical Materials and Interfaces, Shenzhen Institutes of Advanced Technology, Chinese Academy of …Author: Wenhua Zhou, Haodong Cui, Liming Ying, Xue‐Feng Yu
https://pubs.acs.org/doi/10.1021/jacs.8b10947
Protein-based drugs are a promising class of therapeutics, but poor membrane permeability typically limits their application to extracellular receptors. Delivery strategies that can transport functional proteins to reach intracellular targets are needed, but with many current approaches, biomolecules become entrapped in the endosomes. This greatly reduces the effective concentrations of ...Author: Rapeepat Sangsuwan, Phum Tachachartvanich, Matthew B. Francis
https://www.pnas.org/content/116/44/22132
Oct 29, 2019 · Here we demonstrate that IgG antibodies that are conjugated with anionic polypeptides (ApPs) can be complexed with cationic lipids originally designed for nucleic acid delivery through electrostatic interactions, enabling close to 90% cytosolic delivery efficiency with only 500 nM IgG.Author: Hejia Henry Wang, Andrew Tsourkas
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2475621/
Pegylation improves cytosolic delivery of NeutrAvidin conjugates by microporation. Considering the uniform distribution of fluorescently labeled NeutrAvidin observed following microinjection, it was surprising to find that CPPs, SLO and microporation all resulted in punctate fluorescent staining.Author: Antony K. Chen, Mark A. Behlke, Andrew Tsourkas
https://www.nature.com/articles/celldisc20177
Apr 04, 2017 · Cytosolic delivery of antigen is favorable for CTL priming through cross-presentation pathway. However, many commonly studied antigenic peptides cannot be directly and efficiently delivered …Author: Zhida Liu, Zhida Liu, Chang Zhou, Yan Qin, Zihao Wang, Luyao Wang, Xiuli Wei, Yinjian Zhou, Qicheng ...
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