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https://pubs.acs.org/doi/abs/10.1021/nl071542i
Polycations that absorb protons in response to the acidification of endosomes can theoretically disrupt these vesicles via the “proton sponge” effect. To exploit this mechanism, we created nanoparticles with a segregated core−shell structure for efficient, noncytotoxic intracellular drug delivery. Cross-linked polymer nanoparticles were synthesized with a pH-responsive core and ...Author: Yuhua Hu, Tamara Litwin, Arpun R. Nagaraja, Brandon Kwong, Joshua Katz, Nicki Watson, Darrell J. Irv...
https://pubs.acs.org/doi/10.1021/nl071542i
Targeted Cytosolic Delivery of Cell-Impermeable Compounds by Nanoparticle-Mediated, Light-Triggered Endosome Disruption. Nano Letters 2010, 10 (6) , 2211-2219. DOI: 10.1021/nl101157z. Jin-Oh You and Debra T. Auguste.Author: Yuhua Hu, Tamara Litwin, Arpun R. Nagaraja, Brandon Kwong, Joshua Katz, Nicki Watson, Darrell J. Irv...
http://oaktrust.library.tamu.edu/handle/1969.1/154025
Cell-penetrating peptides (CPPs) facilitate the delivery of cell-impermeable macrmolecules across the plasma membrane of live cells. CPPs act as biological Trojan horses by hijacking and inducing endocytosis to enter cells, which leads to entrapment of these peptides inside endocytic organelles.Author: Alfredo Erazo
http://diyhpl.us/~nmz787/pdf/Cytosolic_Delivery_of_Membrane-Impermeable_Molecules_in_Dendritic_Cells_Using_pH-Responsive_CoreShell_Nanoparticles.pdf
Cytosolic delivery of membrane-impermeable molecules into dendritic cells (DCs), immune cells critically involved in the initiation of adaptive immune responses,12-15 is of particular interest. DCs bind peptides derived from pathogens to their major histocompatibility complex (MHC) molecules, and present these peptide-MHC complexes at their ...
https://www.sciencedirect.com/science/article/pii/S0142961219304570
2. Strategies for cytosolic protein delivery. Generally, the strategies for cytosolic protein delivery include physical methods, membrane lytic or endosomolytic agents, cell penetrant peptides or analogues, and the use of nanoparticles, liposomes or polymers to facilitate protein transport across cell membranes.Author: Jia Lv, Qianqian Fan, Hui Wang, Yiyun Cheng, Yiyun Cheng
https://www.nature.com/articles/nchem.2779
May 22, 2017 · The trapping of antibodies in endosomes often limits their use for intracellular targeting. Now, a single amino acid substitution on a spider-venom peptide has been shown to attenuate the cell ...Author: Misao Akishiba, Toshihide Takeuchi, Yoshimasa Kawaguchi, Kentarou Sakamoto, Hao-Hsin Yu, Ikuhiko Nak...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4058846/
Jun 09, 2010 · Schematic of light-activated and targeted cytosolic delivery of membrane-impermeable compounds. (a) Antibody-functionalized nanoparticles are loaded with a model compound (the fluorescent dye Alexa546 in our experiments) and targeted to cells expressing...Author: Sébastien Febvay, Davide M. Marini, Angela M. Belcher, David E. Clapham
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