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https://www.sciencedirect.com/science/article/pii/S0142961219304570
2. Strategies for cytosolic protein delivery. Generally, the strategies for cytosolic protein delivery include physical methods, membrane lytic or endosomolytic agents, cell penetrant peptides or analogues, and the use of nanoparticles, liposomes or polymers to facilitate protein transport across cell membranes.Author: Jia Lv, Qianqian Fan, Hui Wang, Yiyun Cheng, Yiyun Cheng
https://www.nature.com/articles/nchem.2779
May 22, 2017 · One of the major obstacles in intracellular targeting using antibodies is their limited release from endosomes into the cytosol. Here we report …Author: Misao Akishiba, Toshihide Takeuchi, Yoshimasa Kawaguchi, Kentarou Sakamoto, Hao-Hsin Yu, Ikuhiko Nak...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4743495/
Jun 17, 2015 · Quantitative tracking of protein trafficking to the nucleus using cytosolic protein delivery by nanoparticle-stabilized nanocapsules Moumita Ray , † Rui Tang , † Ziwen Jiang , and Vincent M. Rotello *Author: Moumita Ray, Rui Tang, Ziwen Jiang, Vincent M. Rotello
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4314441/
Jan 07, 2015 · We report the use of nanoparticle-stabilized nanocapsules (NPSC) for the direct cytosolic delivery of siRNA. In this approach, siRNA is complexed with cationic arginine-functionalized gold nanoparticles via electrostatic interactions, with the resulting ensemble self-assembled onto the surface of fatty acid nanodroplets to form NPSC/siRNA nanocomplex.Author: Ying Jiang, Rui Tang, Bradley Duncan, Ziwen Jiang, Bo Yan, Rubul Mout, Vincent M. Rotello
https://pubs.acs.org/doi/10.1021/jacs.8b10947
Protein-based drugs are a promising class of therapeutics, but poor membrane permeability typically limits their application to extracellular receptors. Delivery strategies that can transport functional proteins to reach intracellular targets are needed, but with many current approaches, biomolecules become entrapped in the endosomes. This greatly reduces the effective concentrations of ...Author: Rapeepat Sangsuwan, Phum Tachachartvanich, Matthew B. Francis
https://www.pnas.org/content/116/44/22132
Oct 29, 2019 · Here we demonstrate that IgG antibodies that are conjugated with anionic polypeptides (ApPs) can be complexed with cationic lipids originally designed for nucleic acid delivery through electrostatic interactions, enabling close to 90% cytosolic delivery efficiency with only 500 nM IgG.Author: Hejia Henry Wang, Andrew Tsourkas
https://pubs.acs.org/doi/10.1021/acsami.9b21131
Hydrodynamic approaches offer rapid and controllable delivery of small molecules, but thus far have not been demonstrated for delivering functional proteins. In this work, we developed a robust hydrodynamic approach based on gigahertz (GHz) acoustics to achieve rapid and non-invasive cytosolic delivery of biologically active proteins.Author: Shuting Pan, Shuting Pan, Taewon Jeon, David C. Luther, Xuexin Duan, Vincent M. Rotello
https://onlinelibrary.wiley.com/doi/abs/10.1002/anie.201806941
Jun 25, 2018 · Enhanced Cytosolic Delivery and Release of CRISPR/Cas9 by Black Phosphorus Nanosheets for Genome Editing. Dr. Wenhua Zhou. Center for Biomedical Materials and Interfaces, Shenzhen Institutes of Advanced Technology, Chinese Academy of …Author: Wenhua Zhou, Haodong Cui, Liming Ying, Xue‐Feng Yu
https://pubs.rsc.org/en/content/articlelanding/2019/cc/c9cc00010k
Though plenty of viral and non-viral methods have been rapidly developed for the delivery of the CRISPR/Cas9 system, the direct delivery of Cas9 ribonucleoproteins (RNPs) into the nucleus for genome editing via the non-homologous end joining (NHEJ) or homology-directed repair …Author: Jie Qiao, Wenli Sun, Siyu Lin, Rong Jin, Lixin Ma, Yi Liu
https://onlinelibrary.wiley.com/doi/10.1002/anie.201914970
Dec 21, 2019 · Cytosolic protein delivery is a prerequisite for the development of protein therapeutics that act on intracellular targets. Proteins are generally membrane‐impermeable and thus need a carrier such as a polymer to facilitate their internalization.Author: Lanfang Ren, Jia Lv, Hui Wang, Yiyun Cheng, Yiyun Cheng
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