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https://www.nature.com/articles/nchem.2779
May 22, 2017 · The fidelity of this approach was confirmed through the intracellular delivery of a ribosome-inactivation protein (saporin), Cre recombinase and IgG delivery, which resulted in a specific ...Author: Misao Akishiba, Toshihide Takeuchi, Yoshimasa Kawaguchi, Kentarou Sakamoto, Hao-Hsin Yu, Ikuhiko Nak...
https://pubs.acs.org/doi/abs/10.1021/acsnano.7b02884
Endosomal entrapment is a key hurdle for most intracellular protein-based therapeutic strategies. We report a general strategy for efficient delivery of proteins to the cytosol through co-engineering of proteins and nanoparticle vehicles.Author: Rubul Mout, Moumita Ray, Tristan Tay, Kanae Sasaki, Gulen Yesilbag Tonga, Vincent M. Rotello
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4743495/
Jun 17, 2015 · We describe a method for quantitative monitoring of subcellular protein trafficking using nanoparticle-stabilized nanocapsules for protein delivery. This method provides rapid delivery of the protein into the cytosol, eliminating complications from protein homeostasis processes found with cellularly-expressed proteins.Author: Moumita Ray, Rui Tang, Ziwen Jiang, Vincent M. Rotello
https://www.sciencedirect.com/science/article/pii/S0142961219304570
2. Strategies for cytosolic protein delivery. Generally, the strategies for cytosolic protein delivery include physical methods, membrane lytic or endosomolytic agents, cell penetrant peptides or analogues, and the use of nanoparticles, liposomes or polymers to facilitate protein transport across cell membranes.Author: Jia Lv, Qianqian Fan, Hui Wang, Yiyun Cheng, Yiyun Cheng
https://advances.sciencemag.org/content/5/12/eaay3255.full
Dec 01, 2019 · Efficient cytosolic protein delivery is necessary to fully realize the potential of protein therapeutics. Current methods of protein delivery often suffer from low serum tolerance and limited in vivo efficacy. Here, we report the synthesis and validation of a previously unreported class of carboxylated branched poly(β-amino ester)s that can self-assemble into nanoparticles for efficient ...Author: Yuan Rui, David R. Wilson, John Choi, Mahita Varanasi, Katie Sanders, Johan Karlsson, Michael Lim, J...
https://onlinelibrary.wiley.com/doi/10.1002/anie.201914970
Dec 21, 2019 · Cytosolic protein delivery is a prerequisite for the development of protein therapeutics that act on intracellular targets. Proteins are generally membrane‐impermeable and thus need a carrier such as a polymer to facilitate their internalization. However, the efficient binding of proteins with different isoelectric points to polymeric ...Author: Lanfang Ren, Jia Lv, Hui Wang, Yiyun Cheng, Yiyun Cheng
https://pubs.acs.org/doi/abs/10.1021/jacs.8b06584
Nov 01, 2018 · The full potential of protein therapy is, however, being gradually realized by the development of various strategies capable of intracellular protein delivery. Notwithstanding, most of these strategies suffer from severe endosomal trapping, resulting in very low protein delivery efficiency.Author: Shubo Du, Si Si Liew, Lin Li, Shao Q. Yao
https://advances.sciencemag.org/content/5/6/eaaw8922.full
Jun 01, 2019 · Cytosolic protein delivery is of central importance for the development of protein-based biotechnologies and therapeutics; however, efficient intracellular delivery of native proteins remains a challenge. Here, we reported a boronic acid–rich dendrimer with unprecedented efficiency for cytosolic delivery of native proteins.Author: Chongyi Liu, Tao Wan, Hui Wang, Song Zhang, Yuan Ping, Yiyun Cheng, Yiyun Cheng
https://www.nature.com/articles/s41467-018-03779-8
Apr 10, 2018 · To expand the family of protein therapeutics, it is of great importance to develop efficient strategies for cytosolic protein delivery 6,7. Cytosolic protein delivery is challenging since the ...Author: Zhang Z, Shen W, Yan Y, Hu J, Cheng Y
https://www.biorxiv.org/content/biorxiv/early/2017/12/19/236729.full.pdf
- 2 - Engineering of intracellular protein and nucleic acid delivery has been a major challenge in biomedical research for decades1, and numerous strategies have evolved to promote, in particular, the cytosolic delivery of biomacromolecular drugs2.While recent advances haveAuthor: Pavel M. Nikolov, Katja J. Kossmann, Alessa Schilling, Alessandro Angelin, Josipa Brglez, Alina Klei...
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