Cytochrome C Delivery

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Mitochondrial Copper Metabolism and Delivery to Cytochrome ...

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2864105/
    Here we will focus on describing the pathways involved in the delivery of copper to cytochrome c oxidase (COX), a mitochondrial metalloenzyme acting as the terminal enzyme of the mitochondrial respiratory chain. The catalytic core of COX is formed by three mitochondrially-encoded …Author: Darryl Horn, Antonio Barrientos

Inducing cell death in vitro in cancer cells by targeted ...

    https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0195542
    One of the major drawbacks of many of the currently used cancer drugs are off-target effects. Targeted delivery is one method to minimize such unwanted and detrimental events. To actively target lung cancer cells, we have developed a conjugate of the apoptosis inducing protein cytochrome c with transferrin because the transferrin receptor is overexpressed by many rapidly dividing cancer cells ...Author: Manoj Saxena, Yamixa Delgado, Rohit Kumar Sharma, Shweta Sharma, Solimar Liz Ponce De León Guzmán, A...

The Targeted Intracellular Delivery of Cytochrome-C ...

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3307951/
    We have developed a nanoparticle (NP) composed of lipid (DOTAP/DOPE) and apolipoprotein (APO A-I) to mediate the targeted delivery of intracellular-acting protein drugs to non-small cell lung tumors. NPs were produced with either GFP, a fluorescent model protein, or cytochrome C (cytC), an inducer of apoptosis in cancer cells.Author: Sang Kyoon Kim, Michael B. Foote, Leaf Huang

Ferritin nanovehicle for targeted delivery of cytochrome C ...

    https://www.nature.com/articles/s41598-019-48037-z
    Aug 13, 2019 · Cytochrome C delivery to target cells has been demonstrated by Alexa Fluor 555 labelling. Our results show that S-CMHumFt acts as a “Trojan horse” by releasing cytochrome C …Author: Alberto Macone, Silvia Masciarelli, Federica Palombarini, Deborah Quaglio, Alberto Boffi, Matilde Ca...

Delivery of Chemically Glycosylated Cytochrome c ...

    https://pubs.acs.org/doi/10.1021/mp400400j
    Cytochrome c (Cyt c) is a small mitochondrial heme protein involved in the intrinsic apoptotic pathway. Once Cyt c is released into the cytosol, the caspase mediated apoptosis cascade is activated resulting in programmed cell death. Herein, we explore the covalent immobilization of Cyt c into mesoporous silica nanoparticles (MSN) to generate a smart delivery system for intracellular drug ...Author: Méndez J, Morales Cruz M, Delgado Y, Figueroa Cm, Orellano Ea, Morales M, Monteagudo A, Griebenow K

Cytochrome c - A Model Protein for Molecular Evolution ...

    https://www.sigmaaldrich.com/life-science/metabolomics/enzyme-explorer/learning-center/cytochrome-c.html
    Cytochrome c is a highly conserved ~12 kDa protein consisting of a single 104 amino acid peptide with a single heme group, which is covalently attached to Cys and Cys. Because of its ubiquitous nature and sequence homology, cytochrome c has been used as a model protein for molecular evolution.

Mitochondrial copper metabolism and delivery to cytochrome ...

    https://iubmb.onlinelibrary.wiley.com/doi/full/10.1002/iub.50
    Here we will focus on describing the pathways involved in the delivery of copper to cytochrome c oxidase (COX), a mitochondrial metalloenzyme acting as the terminal enzyme of the mitochondrial respiratory chain. The catalytic core of COX is formed by three mitochondrially‐encoded subunits …Author: Darryl Horn, Antonio Barrientos

cytochrome c, cytochrome c Suppliers and Manufacturers at ...

    https://www.alibaba.com/showroom/cytochrome-c.html
    Alibaba.com offers 744 cytochrome c products. About 1% of these are Vitamins, Amino Acids and Coenzymes, 2% are Anti-Allergic Agents, and 2% are Antibiotic and Antimicrobial Agents. A wide variety of cytochrome c options are available to you, such as grade standard.

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