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https://www.sciencedirect.com/science/article/pii/S0168365914002946
Very few of the papers published using chitosan for nasal drug delivery give an adequate characterisation of the chitosan used and hence although results from different studies are compared in this review, it should be noted that some of the differences in the results obtained may be due to differences in the properties of the chitosan or chitosan derivatives used.Author: Luca Casettari, Lisbeth Illum
https://www.sciencedirect.com/science/article/abs/pii/S0168365914002946
The present review discusses the evaluation of chitosan and chitosan derivatives as nasal absorption enhancers, for a range of drugs and in a range of formulations such as solutions, gels and nanoparticles and finds that chitosan and its derivatives are able to efficiently improve the nasal bioavailability.Author: Luca Casettari, Lisbeth Illum
https://link.springer.com/article/10.1023%2FA%3A1018901302450
Aug 01, 1994 · A nasal solution formulation of the cationic material chitosan was shown to greatly enhance the absorption of insulin across the nasal mucosa of rat and sheep. The absorption promoting effect was concentration dependent with the optimal efficacy obtained for concentrations higher than 0.2% and 0.5% in rats and sheep, respectively. The absorption promoting effect was reversible with …Author: Lisbeth Illum, Nidal F. Farraj, Stanley S. Davis
https://www.sciencedirect.com/science/article/pii/S0378517318308147
The poor permeability across the nasal mucosa has become one of the major hurdles for nasal delivery of biopharmaceuticals (Illum, 2012). Several nasal drug delivery systems have been developed to enhance the permeability of biopharmaceuticals across the nasal mucosa, including chitosan-based delivery systems (Casettari and Illum, 2014).Author: Ying Li, Jintian He, Xiaolin Lyu, Yuan Yuan, Gaizhen Wang, Baohua Zhao
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3791944/
Apr 14, 2013 · The positive groups of chitosan enhance its mucoadhesive nature, since it can bind to negatively charged mucosal secretions of the nasal cavity; thus aiding in intranasal drug delivery for the therapy of brain diseases like migraines, Alzheimer’s, epilepsy, tumors, and so on .
I read that cold viruses take 24-48 hours in your nose to start reproducing and causing symptoms, but daily or twice daily irrigation with saline solution washes them out before they can reproduce and make you sick. The Chitosan is a plus as it kills the viruses and helps decrease inflammation. It really opens up your nasal passages, too.
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