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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2426784/
While a variety of polymers and lipids have been employed to form drug- or gene-loaded nanoparticles, one biodegradable polymer that has received a good deal of recent attention as a component of oral drug and gene delivery systems is chitosan.Author: Katherine Bowman, Kam W Leong
https://www.researchgate.net/publication/6116863_Chitosan_Nanoparticles_for_Oral_Drug_and_Gene_Delivery
drug- or gene-loaded nanopar ticles, one biode g radable polymer that has received a good deal of recent attention as a component of oral drug and gene deli very systems is chitosan.
https://pubs.acs.org/doi/10.1021/bm060065f
Recent advances in chitosan-based nanoparticles for oral delivery of macromolecules. ... Recent Advancement of Chitosan-Based Nanoparticles for Oral Controlled Delivery of Insulin and Other Therapeutic Agents. ... using chitosan-based nanoparticles for in vitro and in vivo drug and gene delivery. Expert Opinion on Drug Delivery 2010, 7 (10 ...Author: Feng Qian, Fuying Cui, Jieying Ding, Cui Tang, Chunhua Yin
https://www.sciencedirect.com/science/article/pii/S0939641112001038
Due to its nontoxic character, permeation enhancing properties, and physicochemical characteristics, chitosan is a suitable material for the design of ocular drug delivery systems. Chitosan-based formulations used for ophthalmic drug delivery are hydrogels , nanoparticles , and coated colloidal systems . Chitosan-based systems have the ...Author: Andreas Bernkop-Schnürch, Sarah Dünnhaupt
https://pdfs.semanticscholar.org/0acb/af4b148b99c0492c1e579c02ba515e99c512.pdf
drug- or gene-loaded nanoparticles, one biodegradable polymer that has received a good deal of recent attention as a component of oral drug and gene delivery systems is chitosan. Properties of chitosan Chitosan is a polysaccharide derived from the partial deacetylation of chitin, primarily from crustacean and insect shells.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3090273/
Apr 11, 2011 · Chitosan nanoparticles are good drug carriers because of their good biocompatibility and biodegradability, and can be readily modified. As a new drug delivery system, they have attracted increasing attention for their wide applications in, for example, loading protein drugs, gene drugs, and anticancer chemical drugs, and via various routes of administration including oral, nasal, intravenous ...Author: Jun Jie Wang, Zhao Wu Zeng, Ren Zhong Xiao, Tian Xie, Guang Lin Zhou, Xiao Ri Zhan, Shu Ling Wang
https://www.sciencedirect.com/science/article/pii/S0001868618303865
Martirosyan et al. utilized chitosan to prepare a novel oral gene delivery nanocarrier for the intestinal targeting delivery of 13-mer phosphorothioated gapmers and 21-mer siRNA . Chitosan could interact with mucin fibers via electrostatic interaction, reducing mucosal clearance . They found that the cell uptake of gapmers was not influenced by ...Author: Di Chuan, Tao Jin, Rangrang Fan, Liangxue Zhou, Gang Guo
https://www.semanticscholar.org/paper/Chitosan-nanoparticles-for-oral-drug-and-gene-Bowman-Leong/4f0b1d09c4e4c4aac76df88e2d2054fc4b0f3356
Chitosan is a widely available, mucoadhesive polymer that is able to increase cellular permeability and improve the bioavailability of orally administered protein drugs. It can also be readily formed into nanoparticles able to entrap drugs or condense plasmid DNA. Studies on the formulation and oral delivery of such chitosan nanoparticles have demonstrated their efficacy in enhancing drug ...
https://www.dovepress.com/chitosan-nanoparticles-for-oral-drug-and-gene-delivery-peer-reviewed-article-IJN
Studies on the formulation and oral delivery of such chitosan nanoparticles have demonstrated their efficacy in enhancing drug uptake and promoting gene expression. This review summarizes some of these findings and highlights the potential of chitosan as a component of oral delivery systems. Keywords: chitosan, oral delivery, nanoparticles
http://www.biomedsearch.com/nih/Chitosan-nanoparticles-oral-drug-gene/17722528.html
Chitosan nanoparticles for oral drug delivery. ... More research needs to be conducted on these topics for the rational design of the next generation of oral chitosan drug and gene delivery systems. However, the studies above indicate the feasibility of using chitosan nanoparticles to deliver poorly bioavailable drugs or to achieve in vivo gene ...
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