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https://www.ncbi.nlm.nih.gov/pubmed/29175439
Jan 15, 2018 · Chitosan as a polycationic non-viral vector for gene delivery has the advantage of being a biocompatible and biodegradable polymer. However, without laborious chemical modifications to its structure, it is of limited use as a gene delivery vehicle due to its low ability to efficiently transfect under physiological conditions.Author: Elias Baghdan, Shashank Reddy Pinnapireddy, Boris Strehlow, Konrad H. Engelhardt, Jens Schäfer, Udo ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2426784/
Chitosan nanoparticles for oral gene delivery. Increasingly, nucleic acids are being applied as drugs, both for vaccination and therapeutic gene expression. Chitosan–DNA nanoparticles may be readily formed by coacervation between the positively charged amine groups on the chitosan and negatively charged phosphate groups on the DNA ...Author: Katherine Bowman, Kam W Leong
https://link.springer.com/chapter/10.1007%2F978-3-662-47862-2_22
An efficient gene delivery system for cellular uptake of DNA is essential for gene therapy. Chitosan has been widely used as a promising non-viral carrier for gene delivery. It is a cationic polymer with free amino groups and can bind to anionic nucleic acids spontaneously.Author: Julide Akbuga, Suna Ozbas-Turan, Ceyda Ekentok
https://www.researchgate.net/publication/298818169_Chitosan_Nanoparticles_in_Gene_Delivery
In the case of the natural polymer, chitosan is particularly interesting as a gene carrier due to its biodegradability, biocompatibility, low toxicity and low immunogenicity [6].
https://www.sciencedirect.com/science/article/pii/S0001868618303865
Gene therapy is a promising strategy for treating challenging diseases. The successful delivery of genes is a critical step for gene therapy. However, concerns about immunogenicity and toxicity are the main obstacles against the widespread use of effective viral systems.Author: Di Chuan, Tao Jin, Rangrang Fan, Liangxue Zhou, Gang Guo
https://www.hindawi.com/journals/jnm/2011/952060/
Poly(D,L-lactide-co-glycolide-) (PLGA-)chitosan nanoparticles are becoming an increasingly common choice for the delivery of nucleic acids to cells for various genetic manipulation techniques. These particles are biocompatible, with tunable size and surface properties, possessing an overall positive charge that promotes complex formation with negatively charged nucleic acids. This study ...Author: Hali Bordelon, Alexandru S. Biris, Cristina M. Sabliov, W. Todd Monroe
https://www.researchgate.net/publication/260378681_Applications_of_Chitosan_Nanoparticles_in_Drug_Delivery
This has prompted accelerated research activities worldwide on chitosan micro and nanoparticles as drug delivery vehicles[17] [18] [19][20]all class of bioactive molecules. In view of the recent ...
https://www.sciencedirect.com/science/article/abs/pii/S0753332214000791
Chitosan has been studied for use in particle delivery systems for therapeutic purposes, since one of its most important applications is as a non-viral vector in gene therapy. Due to its positive charge, it is capable of forming DNA complexes (polyplexes) obtained through several methods and with the property of protecting nucleic acids.Author: Carolina Carrillo, Josep Maria Suñé, Pilar Pérez-Lozano, Encarna García-Montoya, Rocío Sarrate, Anna...
https://fenix.tecnico.ulisboa.pt/downloadFile/395145925983/Resumo%2520Tese%2520-%2520Artigo_FINAL.pdf
Preparation and characterization of chitosan nanoparticles for gene delivery Vasco José Dias Duarte Silva Master degree in Biotechnology Abstract: The possibility of using gene-based therapy for treatment of both genetic and acquired diseases such as infections, degenerative disorders or …
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